Lymphomas and leukemias are the most common cancer in children and young adults and in utero exposure to carcinogens may contribute to the etiology of these cancers. A polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DBP), was administered to pregnant mice (15 mg/Kg b.w., gavage) on gestation day 17. Significant mortalities in...
Mercury and arsenic are known developmental toxicants and environmental exposures are ubiquitous worldwide from natural and anthropogenic sources. Prenatal exposure to both contaminants are independently associated with adverse perinatal health outcomes and latent disease risk that could be in part mediated by epigenetic reprogramming events. Fetal programming events involving DNA...
Reports of previous research indicated a stimulatory effect of
triazine herbicides on growth, yield and protein content of plants and
seeds of various species.
Studies were conducted in the greenhouse, laboratory and field
to investigate the effects of atrazine (2-chloro-4-ethylamino-6-a sopropylarnino-
s-triazine) on growth, yield, seed composition, and
seed germination...
In an experimental field study, populations of gray-tailed voles (Microtus canicaudus) were exposed to a commercial formulation of vinclozolin, a fungicide effective for disease control on ornamental plants, turf grasses, and fruits and vegetables. Vinclozolin has been shown in laboratory experiments to behave as an androgen antagonist, impairing the reproductive...
The first study utilized ova transfer in sheep and involved
hormonal treatments for synchronization of estrus and superovulation
in an investigation of crossbred maternal influences on inbred and
linecross lambs.
Synchronization of estrus in ewes was achieved effectively
with either oral progestogen, 6 α-methyl-17α-hydroxy-progesterone
acetate (60 mg./ewe/day), or intramuscular injections...
The aim of this study was to assess sensitivity of early life stage zebrafish to cadmium (Cd). Embryos and larva were exposed to Cd before the formation of skeletal elements. Exposure times were selected to determine whether Cd perturbed developmental processes that lead to skeletal deformities, and to characterize the...