Perinatal growth restriction programs higher risk for chronic disease during adulthood via morphological and physiological changes in organ systems. Perinatal growth restriction is highly correlated with a decreased nephron number, altered renal function and subsequent hypertension. I hypothesize that such renal maladaptations result in altered pharmacologic patterns for life. Pregnant...
In 1992, hundreds of buildings in Taiwan were discovered to have ⁶⁰Co contamination in the structural rebar. The contamination resulted from improper handling of ⁶⁰Co contaminated scrap metal in 1982 and 1983 that was subsequently recycled and used throughout Taiwan. One example was the Hsin-hsin Kindergarten (HHK) school which had...
Tn5 mutagenesis of apdA (for antibiotic production) and deletion of
gacA (for global antibiotic and cyanide) resulted in the same pleiotropic phenotype in
Pseudomonas fluorescens (i.e. production of an array of secondary metabolites
including the antibiotics pyrrolnitrin, pyoluteorin, and 2,4-diacetylphloroglucinol as
well as a tryptophan-side-chain oxidase, hydrogen cyanide, and an...
Many studies addressing the toxicity of silver nanomaterials have found that smaller sized silver nanoparticles are usually more toxic to organisms and in cell culture than particles of larger sizes yet it is not entirely clear why. We investigated the size dependent toxicity of silver nanoparticles by measuring the response...
In 2004 the National Toxicology Program published an article describing their intent to pursue toxicology testing and risk assessment practices solely reliant on high throughput in vitro datasets and in silico modeling for dose-response assessments. Support and contributions form regulatory agencies and a significant portion of the life sciences community...