Diatoms are single celled algae that form cell walls made primarily of silicon
dioxide (SO₂). The metabolic machinery that gives diatoms the ability to biogenically
form highly ordered solid silica from soluble silicon extracted from their external
environment provides a unique platform to create novel nanostructured materials
inexpensively and with...
Every cell is faced continuously with the task of transducing a vast number of external signals into appropriate intracellular responses. In mammalian cells, membrane bound receptors modulate the production of secondary messenger molecules, such as cyclic AMP (cAMP). Cell signaling through second messengers relies on the diffusion of such second...
Boron has been recognized since 1923 as an essential
micronutrient for vascular plants, but its function is
still not known. Many diverse roles have been proposed,
but none of these has been definitively shown. Problems
that have made the study of the function of boron
difficult include, no useful radioisotope,...
By salt depleting the animals or by injecting them with
aldosterone, I was able to increase the active transport of sodium
across the isolated skin. The potential difference was increased
by 37% and 43% respectively and the net sodium flux by 69% and
62%. Exposure of frogs to 50 mM...
This thesis details my investigation of some pharmaceuticals and natural products on the transport of drugs which are substrates of P-glycoprotein (P-gp), such as cyclosporin A (CSA) and digoxin by using Caco-2 and MDCKII-MDR1 drug transport models. Three objectives were performed to address this goal. The first objective was to...
Elite milers, Sir Roger Bannister and Joseph Falcon, have stated that the
consumption of carbonated beverages hinders the performance of aerobic
events. Oxygen transport is purportedly impaired by the consumption of
carbonated beverages. The research on carbonated beverages has been
limited to the effects on the digestive system, gastric emptying,...
This thesis describes in vitro and in vivo evaluation of a gastric retention formulation (GRF) developed at Oregon State University. The formulation was prepared from xanthan gum and locust bean gum as gelling agents and other formulation ingredients were added, then it was originally vacuum oven dried. The effect of...