Na⁺/H⁺ antiporters are ubiquitous membrane proteins that play a central role in the ion homeostasis of cells. In this study, we examined the possible role of Na⁺/H⁺ antiport in Yersinia pestis virulence and found that Y. pestis strains lacking the major Na⁺/H⁺ antiporters, NhaA and NhaB, are completely attenuated in...
We found that a strains of Yersinia pestis (KIM5) which lacked the nhaA gene was fully attenuated in a plague model. This gene produces a protein of the sodium-proton antiporter family which expel sodium ions from the bacterial cytoplasm in exchange for hydrogen ions, or protons, from the surrounding environment....
Full Text:
Virulence of Yersinia pestis
Wyatt J. Faulkner2, Amit Ghosh1, Yusuke Minato1, Judith
We found that a strains of Yersinia pestis (KIM5) which lacked the nhaA gene was fully attenuated in a plague model. This gene produces a protein of the sodium-proton antiporter family which expel sodium ions from the bacterial cytoplasm in exchange for hydrogen ions, or protons, from the surrounding environment....
Full Text:
Virulence of Yersinia pestis
Wyatt J. Faulkner2, Amit Ghosh1, Yusuke Minato1, Judith Winogrodzki
We found that a strains of Yersinia pestis (KIM5) which lacked the nhaA gene was fully attenuated in a plague model. This gene produces a protein of the sodium-proton antiporter family which expel sodium ions from the bacterial cytoplasm in exchange for hydrogen ions, or protons, from the surrounding environment....
The advancement of artificial intelligence (AI) has led to transformative developments across multiple sectors, fostering innovation and redefining our interactions with technology. As AI matures and becomes integrated into society, it offers numerous opportunities to address global challenges and revolutionize a wide array of human endeavors. These advances are driven...
T cells are one of the key cells in the immune system. Although they are not the first line of defense against a pathogen, their functions can greatly enhance the phagocytosis and destruction of pathogens as well as the development of antibody responses. Furthermore, even when responding T cells have...
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Bedrock meandering rivers are sinuous channels that pair steep bedrock outside banks with lower gradient slip-off slopes on the inside of bends. These rivers have the potential to record information on climatic and tectonic “external” forcings in their morphology (e.g., longitudinal profiles, strath terraces, channel and valley dimensions). However, geology...
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Cnidarians, such as corals and sea anemones serve as hosts to a variety of organisms including symbiotic dinoflagellates, bacteria, virus, and apicomplexans. As corals are vital to the health and productivity of the reef ecosystem it is important to understand how these organisms interact with each component of the holobiont....