Old-growth in the Pacific Northwest is generally defined as trees that are more
than 200 years old. A great deal of analysis and discussion about old-growth forests in
western Oregon, however, has focused on the relatively widespread 400 to 500 year
age class of primarily Douglas-fir (Pseudotsuga menziesii) trees. The...
The down‐regulation of dominant oncogenes, including C‐MYC, in tumor cells often leads to the induction of
senescence via mechanisms that are not completely identified. In the current study, we demonstrate that MYC‐depleted
melanoma cells undergo extensive DNA damage that is caused by the underexpression of thymidylate synthase (TS) and
ribonucleotide...
In normal human cells, oncogene-induced senescence (OIS) depends on induction of DNA damage response (DDR). Oxidative stress and hyper-replication of genomic DNA have been proposed as major causes of DNA damage in OIS cells. Here we report that down-regulation of deoxyribonucleoside pools is another endogenous source of DNA damage in...
