Changes in dietary selenium and selenoprotein status may influence both anti- and pro-cancer pathways, making the outcome of interventions different from one study to another. To characterize such outcomes in a defined setting, we undertook a controlled hepatocarcinogenesis study involving varying levels of dietary selenium and altered selenoprotein status using...
Over the last ten years, clinical, pre-clinical and animal studies have shown associations between the microbiota and neurological functions. Recent work by the scientific community on the gut-microbiome-brain axis have revealed that gut dysbiosis and specific microbial taxa are associated with a myriad of neurological conditions, such as autism spectrum...
The study of the diversity of multivariate objects shares common characteristics across disciplines, including ecology and organizational management. Nevertheless, experts in these two disciplines have adopted somewhat separate diversity concepts and analysis techniques, limiting the ability of potentially sharing and cross comparing these concerns. Moreover, while complex diversity data may...
Single-scattering tomography describes a model of photon transfer through a object in which photons are assumed to scatter at most once. The Broken Ray transform arises from this model, and was first investigated by Lucia Florescu, Vadim A. Markel, and John C. Schotland, [2], in 2010, followed by an inversion,...
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transform arises
from this model, and was first investigated by Lucia Florescu, Vadim A. Markel, and John
Selenoprotein W (SeW) is a protein whose function is unknown, but potentially plays a vital role in calcium metabolism, as an indirect link has been established with white muscle disease (WMD). White muscle disease occurs in selenium deficient animals, and is characterized by the precipitation of calcium in muscle, leading...
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White muscle disease (WMD), a degenerative muscle disease brought on by a deficiency of the essential trace nutrient selenium, is thought to be mediated by the protein Selenoprotein W (SeW). In its relationship with WMD, SeW, like many selenoproteins, binds to glutathione, serving some purpose in redox mechanisms...
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., Lobanov A. V., Zehtab O., Guigó R., and Gladyshev V. N. (2003). "Characterization of mammalian
Protein disulfide isomerase (PDI), a member of the thioredoxin superfamily, contains two domains with significant sequence homology to the active sites in thioredoxin. PDI facilitates the folding of nascent proteins in the endoplasmic reticulum (ER), binds hormones and Ca²⁺, catalyzes the glutathione dependent reduction of dehydroascorbate, serves as a major...
DNA is often described as the “blueprint for life”. In eukaryotes this information is contained within linear chromosomes of varying size and number. During cell division, the chromosomes must be faithfully segregated into each daughter cell to avoid disease and sustain life. This process is carried out by the kinetochore...
The phenolic profile of pineapple juice was analyzed by reverse-phase HPLC/Diode Array Detector, and 9 major peaks accounting for 70% of total peak area were characterized. None of these peaks are represented by the pineapple phenolics reported to be present by previous workers. Most of the major peaks are not...
Immunosuppression during the periparturient period leads to increased susceptibility to infectious diseases in beef cows. Newborn calves rely on passive transfer of antibodies from their mothers at birth for protection against diseases in the first two months of age. It is unknown if supranutritional Se supplementation of cows during pregnancy...