Placental pathologies are not uncommon in dogs. For example, in primiparous bitches, the reported incidence of subinvolution of placental sites is 21% - 100%. Despite years of research in multiple species, the mechanisms regulating late gestation trophoblast behavior in the dog remain unexamined. Therefore, the objective of this study was...
BACKGROUND: This investigation sought to elucidate the relationship between hepatocyte growth factor (HGF)–induced metastatic behavior and the tyrosine kinase inhibitors (TKIs) crizotinib and dasatinib in canine osteosarcoma (OS). Preliminary evidence of an apparent clinical benefit from adjuvant therapy with dasatinib in four dogs is described. METHODS: The inhibitors were assessed...
Transcriptome gene expression studies of sperm RNA have been utilized in a variety of different species to investigate causes of male infertility. Previous research investigators have optimized cell separation and RNA isolation techniques for each species of interest. To date, no study has been completed for dogs. The objective of...
Reproductive function in the dog is controlled by feedback mechanisms that involve the hypothalamus, the anterior pituitary gland, and the gonads. Surgical gonad removal, a common procedure performed in dogs for the purposes of sterilization, disrupts the hypothalamic-pituitary-gonadal (HPG) axis and results in permanently elevated concentrations of gonadotropins. Manipulation of...
This research investigated gene expression in the canine placenta during the peripartum period. Previous studies have recognized molecular changes that occur in the placenta around the time of placental release in other species, but no study has looked at gene expression in the late gestation canine placenta. Of particular significance...