Human cathelicidin antimicrobial peptide (CAMP/LL-37) is a cationic antimicrobial peptide that is widely expressed by myeloid and epithelial cells at the human-environment interface. It possesses broad spectrum antimicrobial capacity against bacteria, fungi and viruses. In addition to its direct antimicrobial activity, CAMP/LL-37 also attracts and recruits monocytes, neutrophils and other...
The vitamin D receptor (VDR) mediates the pleiotropic biologic effects of 1alpha,25
dihydroxy-vitamin D3. Recent in vitro studies suggested that curcumin and poly-unsaturated fatty
acids (PUFAs) also bind to VDR with low affinity. As potential ligands for the VDR, we hypothesized
that curcumin and PUFAs would induce expression of known...