Search Constraints

Start Over
Filtering by: Committee Member Ho, Oui Shing Remove constraint Committee Member: Ho, Oui Shing

Search Results

  • Regulation of ribonucleotide reductase analyzed by simultaneous measurement of the four enzyme activities

    Creator:
    Hendricks, Stephen P.
    Abstract:
    The first committed step in DNA biosynthesis occurs by direct reduction of ribonucleotides. This reduction is catalyzed by ribonucleotide reductase (RNR), an enzyme which uses a unique radical mechanism to facilitate the transformation. All four DNA precursors are synthesized by a single enzyme. Therefore, an intricate pattern of regulation has...
    Resource Type:
    Dissertation
    Full Text:
    members, Drs. Pui Shing Ho, Victor L. Hsu, William H. Gerwick, and Russel H. Meints for the time and

  • Structural requirements for adenovirus DNA replication

    Creator:
    Hu, Chin-Hwa
    Abstract:
    The adenovirus replication origins reside in the inverted terminal repetition (ITR) sequences. Replication proceeds unidirectionally by a strand-displacement mechanism from either or both origins to produce duplex daughter DNA plus a displaced parental strand. The displaced strand can be duplicated by two different routes. The cis pathway involves intramolecular hybridization...
    Resource Type:
    Dissertation
    Full Text:
    . Pui Shing Ho, Dr. Dennis Hruby, and Dr. Peter Bottom ley, for their generous help. I also want to

  • Sequence conversion during adenovirus DNA replication

    Creator:
    Bennett, Kelly L.
    Abstract:
    The work in this thesis has provided conclusive genetic evidence that "panhandle" intermediates form during adenovirus replication. Adenovirus chromosomes lacking 51 by from their left -hand termini are infectious and capable of regenerating the missing origin sequence. Yet if an entire inverted terminal repeat is removed, the adenovirus chromosome is...
    Resource Type:
    Dissertation
    Full Text:
    extend my gratitude to my committee members, Dr. Christopher Mathews, Dr. Pui Shing Ho, Dr. Dal lice

  • Effects of nucleosomes on transcription by polymerase I in a reconstituted system

    Creator:
    Georgel, Philippe, 1961-
    Abstract:
    The aim of this study was to gain more information about the interactions between DNA and the histone octamer during the process of transcription. This work used a pUC8 plasmid derivative that contained the core promoter region of the RNA polymerase I of Acanthamoeba castellanii, placed upstream of four repeats...
    Resource Type:
    Dissertation
    Full Text:
    his support. All the members of my committee, professor Pui Shing Ho, professor Henry Schaup

  • Bacteriophage T4 ribonucleotide reductase : genes and proteins

    Creator:
    Hanson, Eric Scott
    Resource Type:
    Dissertation
    Full Text:
    . Lastly, I thank the members of my committee, Drs. Christopher Mathews, Douglas Barofsky, Shing Ho, Jo-Ann

  • Automethylation : a response to enzyme aging

    Creator:
    Lindquist, Jonathan A.
    Abstract:
    This is the first study to explore the ability of an enzyme to recognize and repair spontaneous age-dependent damage to its own sequence. Protein (D-aspartyl/L-isoaspartyl) carboxyl methyltransferase (PCM) is known to repair damage that arises from a spontaneous isomerization of aspartyl and asparaginyl residues in other proteins during aging. As...
    Resource Type:
    Dissertation
    Full Text:
    . P. Shing Ho, Dr. Michael Schimerlik, and Dr. Carmen Somoza. And I would especially like to thank

  • DNA binding and beyond : an investigation of proteins involved in PAH-induced carcinogesesis

    Creator:
    Hooven, Louisa Ada
    Abstract:
    Exposure to polycyclic aromatic hydrocarbons such as benzo[a]pyrene (B[a]P) has been determined to be a risk factor for various forms of human cancer. PAH DNA adducts have been shown to cause mutations, but carcinogenesis is also accompanied by alterations in gene expression. Inhibiting individual cytochrome P450s could clarify the interaction...
    Resource Type:
    Dissertation
    Full Text:
    unwavering support. My appreciation is also extended to Dr. P. Shing Ho, Dr. Christopher K. Mathews, and Dr

  • Electron molecule interactions of amino acids and peptides

    Creator:
    Figard, Benjamin J.
    Abstract:
    Electron-biomolecule interactions are a biologically relevant field of study because there are several ion fragmentation techniques that have come to the forefront in mass spectrometric analysis that involve the interaction of charged peptides and free electrons. By studying the electron energies that cause fragmentation in neutral amino acids, amino acid...
    Resource Type:
    Dissertation

  • Helical propensity of amino acids changes with solvent environment

    Creator:
    Krittanai, Chartchai
    Resource Type:
    Dissertation
    Full Text:
    committee members, Dr. Pui Shing Ho, Dr. Victor L. Hsu, Dr. Joseph W. Nib ler, and Dr. Carol J. Rivin for

  • Towards the understanding of the function of the histone "tails" with respect to the structure, stability, and function of chromatin

    Creator:
    Dong, Feng
    Abstract:
    By using immobilized trypsin, I have been able to prepare well-defined, stable trypsinized nucleosomes. The difficulties of lacking of control in the extent of trypsinization, which were encountered in previous studies with the use of free trypsin, have been eliminated. The nucleosomes and oligonucleosomes prepared by immobilized trypsin are suitable...
    Resource Type:
    Dissertation
    Full Text:
    graduate committee members, Dr. George Bailey, Dr. Shing Ho, Dr. Christopher Mathews, and Dr. John Morris