Index Catalog // ScholarsArchive@OSU

Development of a system to test for the toxicity of solar irradiated polynuclear aromatic hydrocarbons and preliminary data using mammalian cell cultures

Creator:: McNair, Vannin Marie Hutchinson
Abstract:: Polynuclear aromatic hydrocarbons (PNAH) classified as noncarcinogens may be photooxidized to mutagenic or toxic products by near-ultraviolet (NUV) wavelengths of sunlight (290-320 nm). The possibility that this represents a major degredation pathway in the aquatic environment is of increasing concern. Large quantities of PNAH from accidental oil spills, anthropogenic and...
Resource Type:: Masters Thesis
Full Text:: important, but so are certain PNAH degra- dation products. 4 Polynuclear aromatic hydrocarbon airborne

Unraveling tissue regeneration using chemical genetics

Creator:: Mathew, Lijoy K.
Abstract:: The emerging field of regenerative medicine is mainly approached by two different aspects. First is the use of stem cell based models to generate a suite of differentiated cells for therapeutic applications and the alternative approach is to utilize the non-mammalian models that have the inherent capacity to regenerate their...
Resource Type:: Dissertation
Full Text:: . Mathew for the degree of Doctor of Philosophy in Toxicology presented on October 29, 2007. Title

DNA binding and beyond : an investigation of proteins involved in PAH-induced carcinogesesis

Creator:: Hooven, Louisa Ada
Abstract:: Exposure to polycyclic aromatic hydrocarbons such as benzo[a]pyrene (B[a]P) has been determined to be a risk factor for various forms of human cancer. PAH DNA adducts have been shown to cause mutations, but carcinogenesis is also accompanied by alterations in gene expression. Inhibiting individual cytochrome P450s could clarify the interaction...
Resource Type:: Dissertation
Full Text:: Biophysics, 2Department of Environmental and Molecular Toxicology Oregon State University, Corvallis

Advances in Passive Sampling : Measuring Chemical Transport and Human Exposures

Creator:: Donald, Carey E.
Abstract:: Passive sampling devices have been used for decades to measure complex mixtures of bioavailable organic chemicals in a variety of environmental media. More recently passive sampler applications have expanded beyond monitoring chemical concentrations, and this dissertation continues to advance methods of passive sampling on many fronts. Despite their growing use,...
Resource Type:: Dissertation
Full Text:: E. Donald for the degree of Doctor of Philosophy in Toxicology presented on April 17, 2017 Title

Defining PAH and Oxygen-substituted PAH-dependent Developmental and Adult Toxicity in Zebrafish

Creator:: Knecht, Andrea L.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) and oxygen-substituted PAHs (OPAHs) are environmental contaminants present in urban air, dust, soil and water resulting from incomplete combustion of organic materials or fossil fuels; found in crude oil and coal; and formed through photoxidation or biotransformation of microbial. It is widely recognized that PAHs pose...
Resource Type:: Dissertation
Full Text:: . Inferences can be drawn from the known toxicology of napthoquinones, which bind to biomacromolecules; and

Developmental toxicity of polycyclic aromatic hydrocarbons : defining mechanisms with systems-based transcriptional profiling

Creator:: Goodale, Britton C.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment as components of fossil fuels and by-products of combustion. Defining toxicity mechanisms for this large family of multi-ring structures and substituted derivatives is a substantial challenge. Several PAHs, such as benzo(a)pyrene (BaP), are mutagenic, toxic to wildlife, and classified as probable...
Resource Type:: Dissertation
Full Text:: Britton C. Goodale for the degree of Doctor of Philosophy in Toxicology presented on August 12, 2013

Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

Creator:: Chlebowski, Anna C.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are among the most widely known and studied environmental contaminants, originating from a range of natural and anthropogenic sources. PAHs are known to occur in the environment as complex mixtures, containing both unsubstituted PAHs, as well as a range of PAH derivatives. Among the less-studied of...
Resource Type:: Dissertation
Full Text:: in Toxicology presented on April 10, 2017. Title: Utilization of the Zebrafish Model for

Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

Creator:: Madeen, Erin
Abstract:: The objective of this work is to add to the body of translational data between high dose animal model research and the environmentally relevant human metabolism of the persistent pollutant dibenzo[def,p]chrysene (DBC). We furthered the knowledge of gene/exposure interactions by determining the carcinogenesis risk based on Cyp1b1 genotype following in...
Resource Type:: Dissertation
Full Text:: ABSTRACT OF THE DISSERTATION OF Erin Madeen for the degree of Doctor of Philosophy in Toxicology

Molecular and cellular mechanisms of aromatic hydrocarbon axonopathy

Creator:: Kim, Min-Sun
Abstract:: Hydrocarbon solvents are widely used in the production of paints, adhesives, dyes, polymers, plastics, textiles, printing inks, agricultural products and pharmaceuticals. While the neuropathic potential of aliphatic solvents was shown in the 1970s, little is known about the neuropathic potential of aromatic solvents. The present study examines such solvents, 1,2-diethylbenzene...
Resource Type:: Dissertation
Full Text:: Molecular and cellular mechanisms of aromatic hydrocarbon

Human exposure to polycyclic aromatic hydrocarbons : global cancer risk and metabolism

Creator:: Motorykin, Oleksii
Abstract:: In recent decades, there has been increased attention on human exposure to, and subsequently toxicity of, Polycyclic Aromatic Hydrocarbons (PAHs). PAHs are widespread organic pollutants and some have been shown to be toxic, carcinogenic and mutagenic. This research was focused on understanding the link between global PAH emissions and lung...
Resource Type:: Dissertation
Full Text:: staff in the Chemistry and Environmental and Molecular Toxicology departments at Oregon State

ScholarsArchive@OSU

Development of a system to test for the toxicity of solar irradiated polynuclear aromatic hydrocarbons and preliminary data using mammalian cell cultures

Unraveling tissue regeneration using chemical genetics

DNA binding and beyond : an investigation of proteins involved in PAH-induced carcinogesesis

Advances in Passive Sampling : Measuring Chemical Transport and Human Exposures

Defining PAH and Oxygen-substituted PAH-dependent Developmental and Adult Toxicity in Zebrafish

Developmental toxicity of polycyclic aromatic hydrocarbons : defining mechanisms with systems-based transcriptional profiling

Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

Molecular and cellular mechanisms of aromatic hydrocarbon axonopathy

Human exposure to polycyclic aromatic hydrocarbons : global cancer risk and metabolism

Limit your search

Academic Affiliation

Advisor

Commencement Year

Committee Member

Creator

Date

Decade

Degree Field

Degree Level

Degree Name

File Format

Language

License

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Subject

Search Constraints

Search Results

Limit your search