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  • Effect of PFAS Exposure on Reproduction : a Comparative Investigation between Kisspeptin-secreting AVPV and Arcuate Nuclei

    Creator:
    Jacobs, Dakota
    Abstract:
    Ovulation requires preovulatory surges of gonadotropin-releasing hormone (GnRH) from preoptic hypothalamic neurons, initiated by elevated ovarian estradiol (E₂). Rising estradiol activates a subset of sexually dimorphic kisspeptin (Kiss-1) neurons in the female, located in the anteroventral periventricular nuclei (AVPV). Conversely, estradiol negative feedback on GnRH secretion is mediated by a...
    Resource Type:
    Masters Thesis
    Full Text:
    ABSTRACT OF THE THESIS OF Dakota Jacobs for the degree of Master of Science in Toxicology presented on

  • Generation of Kisspeptin Cell Lines to Investigate the Sex Steroid-Mediated Initiation of Puberty

    Creator:
    Jacobs, Dakota C.
    Abstract:
    Mammalian female reproduction requires preovulatory surges of gonadotropin-releasing hormone (GnRH) from neurons in the preoptic area (POA) of the hypothalamus, initiated by elevated estradiol (E₂). Rising E₂ activates a subset ofsexually dimorphic Kisspeptin neurons in the female, located in the anteroventralperiventricular nuclei (AVPV). Conversely, E₂ negative feedback is mediated by...
    Resource Type:
    Presentation and Undergraduate Thesis

  • Jacobs Seminar.pdf

    Creator:
    Jacobs, Dakota C. and Giebultowicz, Jadwiga M.
    Abstract:
    Mammalian female reproduction requires preovulatory surges of gonadotropin-releasing hormone (GnRH) from neurons in the preoptic area (POA) of the hypothalamus, initiated by elevated estradiol (E₂). Rising E₂ activates a subset ofsexually dimorphic Kisspeptin neurons in the female, located in the anteroventralperiventricular nuclei (AVPV). Conversely, E₂ negative feedback is mediated by...
    Full Text:
    role in puberty Generating kisspeptin cell lines to investigate their role in reproduction Dakota

  • JacobsBRR Final Thesis.pdf

    Creator:
    Jacobs, Dakota C. and Giebultowicz, Jadwiga M.
    Abstract:
    Mammalian female reproduction requires preovulatory surges of gonadotropin-releasing hormone (GnRH) from neurons in the preoptic area (POA) of the hypothalamus, initiated by elevated estradiol (E₂). Rising E₂ activates a subset ofsexually dimorphic Kisspeptin neurons in the female, located in the anteroventralperiventricular nuclei (AVPV). Conversely, E₂ negative feedback is mediated by...
    Full Text:
    Steroid-Mediated Initiation of Puberty Dakota C. Jacobs1, Jadwiga M. Giebultowicz2,and Patrick E