In biological systems, antioxidants are bioactive compounds that protect against oxidation of lipids, proteins, and DNA. Natural antioxidant peptides are often purified and isolated from proteins as a less toxic alternative to synthetic peptides, but the mechanisms behind their activity are not well understood. The purpose of this study is...
Ample research has demonstrated the largely untapped potential of bioactive peptides (BAPs) for treating systematic chronic inflammation (SCI). Protein hydrolysates are the mixture of peptides resulting from the hydrolytic breakdown of a protein. Numerous hydrolysates contain BAPs and exert beneficial effects in both in vitro and in vivo models. In...
The seafood industry has a problem of underutilization of harvested and processed fish. Up to 60% of the weight of the fish is considered a byproduct that is typically made into fishmeal for livestock and aquaculture feed, a low-value and non-food grade product. Two species that make up major fisheries...
Seaweeds have gained tremendous recognition as a highly nutritious and sustainable crop. The diverse components of seaweeds are known to exhibit a wide range of bioactivities, including anti-inflammatory, anti-diabetic, and cardiovascular health benefits. One such promising seaweed is Pacific dulse (Devaleraea mollis). While it holds great cultivating potential on the...
Thermal distress in asphalt concrete pavements is a widespread problem around
the world. Thermal cracking can be divided into two modes of distress: low
temperature cracking and thermal fatigue cracking. Low temperature cracking results
from extremely cold temperatures; thermal fatigue cracking results from daily
temperature cycles.
Low temperature cracking is...
A sophisticated computer program is developed to analyze flow linear
dichroism data on nucleic acids for individual base inclinations. Measured
absorption and linear dichroism data for synthetic AT and GC polymers and
natural DNAs are analyzed. The reliability of the program is tested on data for
the synthetic polymers, and...
The effects of the residual salt of surimi on biochemical and physical properties as affected by various freeze and thaw cycles were examined. Fresh Alaska pollock (Theragra chalcogramma) surimi was mixed with 4.0% sugar, and 5.0% sorbitol, along with eight combinations of salt (0.4, 0.6, 0.8, and 1.0 % NaCl)...
Escherichia coli double-strand uracil-DNA glycosylase (Dug) was purified to apparent homogeneity from bacteria that were defective in uracil-DNA glycosylase (Ung). After cloning the dug gene, recombinant Dug was overexpressed, purified, and characterized with respect to activity, substrate specificity, product DNA binding, and mechanism of action. Purified Dug excised both uracil...
Glycomacropeptide (GMP) is a bioactive peptide found in the dairy product whey, along with whey protein isolate (WPI). Past studies have shown that digested GMP retains bioactivity in rodent guts. This study tested whether GMP or GMP-derived peptides or whey protein or whey protein-derived peptides inhibit pro-inflammatory cytokines. THP-1 cells...