BACKGROUND: Cell lineage-specific DNA methylation patterns distinguish normal human leukocyte subsets and can
be used to detect and quantify these subsets in peripheral blood. We have developed an approach that uses DNA
methylation to simultaneously quantify multiple leukocyte subsets, enabling investigation of immune modulations
in virtually any blood sample including...
BACKGROUND: Cell lineage-specific DNA methylation patterns distinguish normal human leukocyte subsets and can
be used to detect and quantify these subsets in peripheral blood. We have developed an approach that uses DNA
methylation to simultaneously quantify multiple leukocyte subsets, enabling investigation of immune modulations
in virtually any blood sample including...
Full Text:
Open Access
Quantitative reconstruction of leukocyte
subsets using DNA methylation
William P Accomando1
BACKGROUND: Cell lineage-specific DNA methylation patterns distinguish normal human leukocyte subsets and can be used to detect and quantify these subsets in peripheral blood. We have developed an approach that uses DNA methylation to simultaneously quantify multiple leukocyte subsets, enabling investigation of immune modulations in virtually any blood sample including...
Cosmogenic-burial and U-series dating, identification of fluvial terraces and lacustrine
deposits, and river-profile reconstructions show that capture of the Gunnison River by
the Colorado River and abandonment of Unaweep Canyon occurred between 1.4-0.8
Ma. This event led to a rapid pulse of incision unlike any documented in the Rocky
Mountains....
Background: There has been a long-standing need in biomedical research for a method that quantifies the normally mixed composition of leukocytes beyond what is possible by simple histological or flow cytometric assessments. The latter is restricted by the labile nature of protein epitopes, requirements for cell processing, and timely cell...
