Although female athletes are at greater risk of non-contact knee injuries than men, the factors that contribute to these injuries are not well understood. One important question is whether intense exercise influences the risk of knee injury, both acutely
and over the following days. The purpose of this study was...
A functional test battery (FTB), which combines the use of subjective and objective functional measures, has been proposed as a potential means to distinguish anterior cruciate ligament reconstructed (ACLR) patients' that can more safely participate in activity from those at greater risk. However, no previous study has directly assessed whether...
Anterior cruciate ligament injuries are common in a wide variety of sports and most frequently occur during activities requiring rapid deceleration such as landing and cutting. Deceleration of the body's center of mass during movement results primarily from eccentric muscle contraction. This type of contraction serves to absorb energy from...
Calcium channel blockers (CCB) was studied extensively in cardiology for their tissue
protective effect following myocardial infarction; we hypothesized that administration of
a CCB would interfere with the processes that result in exercise-induced muscle damage
(EIMD) and delayed onset muscle soreness. To investigate the effects of a CCB on a...
Skeletal muscle damage induced by lengthening ("eccentric" or
"pliometric") contractions cause an immediate loss in maximal tetanic force (P₀) and an increase in protein degradation by unidentified endogenous mechanisms.
We hypothesized that increased proteolysis following active lengthening injury is
mediated by the Ca²⁺ dependent protease calpain. To test this hypothesis...
Despite years of research, females continue to have a higher incidence of non-contact ACL injuries. One of the major findings of this research is that males and females perform certain tasks, such as, cutting, landing, and single-leg squatting, differently. In particular, females tend to move the knee into a more...
Tibial stress fractures are common in runners. However, it is unclear what factors are associated with tibial stress fractures. This study aimed to investigate 1) magnitudes of bone contact forces occurring while running 2) whether or not repeated application of running loads is sufficient to explain tibial stress fractures and...
Calcium activated proteases, or calpains, are activated in cardiac muscles under conditions of ischemia/reperfusion and hypoxia. Their activity in skeletal muscle under similar conditions is poorly understood. We tested the hypothesis that hypoxia elevates calpain-mediated proteolysis in isolated glycolytic (extensor digitorum longus, EDL) and oxidative (soleus, SOL) mouse muscles studied...
We hypothesized that calpain activity is elevated in response to muscle damage. To test this hypothesis, we examined the degradation of α-fodrin into its 150 and 145 kDa fragments following either 20 eccentric or isometric contractions. In addition, experiments were performed in the presence or absence of E-64-d, a calpain...
To determine if 6 weeks prior supplementation with vitamins E and C
could alleviate exercise-induced DNA damage, prevent lipid peroxidation and
inflammation, slow the rate of vitamin E utilization and/or attenuate muscle
damage, 22 subjects (11 females: 11 males) were studied during a 50 km (32
mile) ultramarathon. Subjects were...