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  • Strength in Numbers: How Multivalent WW-PPXY Interactions Regulate Cell Signaling

    Creator:
    Vogel, Amber J.
    Abstract:
    Cell signaling is often mediated by protein-protein interactions, which must be specific, tunable, and transient to allow agile responsiveness to cellular messages. Due to their unique properties, multivalent, intrinsically disordered proteins make ideal candidates to accomplish these vital tasks. A single protein with multiple binding sites may bind numerous partners,...
    Resource Type:
    Dissertation
    Full Text:
    committee members: Dr. Elisar Barbar, Dr. Richard Cooley, Dr. Siva Kolluri, Dr. Glencora Borradaile, and

  • Investigations of the AhR-induced Treg : transcriptional regulation and suppressive mechanisms

    Creator:
    Rohlman, Diana
    Abstract:
    The aryl hydrocarbon receptor (AhR) has recently been described as a novel therapeutic target, given the potent suppression of multiple immune-mediated diseases following activation by the prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In the parent-into-F1 graft-versus-host (GVH) model, suppression of the cytotoxic T-lymphocyte (CTL) response is associated with the presence of CD25⁺CTLA-4⁺IL-10⁺Foxp3[superscript...
    Resource Type:
    Dissertation
    Full Text:
    . To my committee members: Dr. Malcolm Lowry, Dr. Siva Kolluri, Dr. Mark Leid and Dr. Patricia Dysart

  • Acute exposure to ethionamide in an Fmo 1/2/4 null murine model

    Creator:
    Palmer, Amy L.
    Abstract:
    The use of ethionamide has been increasing in drug regiments due to greater incidence of multidrug resistance tuberculosis around the world. Ethionamide is metabolized into antimicrobial relevant compounds by different flavin-containing monooxygenase (FMO) enzymes including FMO1, FMO2, and FMO3. FMOs are found in various locations in the body including the...
    Resource Type:
    Masters Thesis

  • Transcriptomic approaches for discovering regenerative and developmental regulatory networks in zebrafish

    Creator:
    Garland, Michael A.
    Abstract:
    Zebrafish are capable of fully regenerating organs and tissue such as their caudal fin, which is similar to a human regrowing an arm or a leg. In contrast, most mammals including humans have a greatly reduced capacity for wound healing. The ability of zebrafish to undergo this regenerative process, called...
    Resource Type:
    Dissertation
    Full Text:
    like to thank my committee: Dr. Siva Kolluri, who supported me during my laboratory rotation and

  • Characterization and Validation of Neisseria gonorrhoeae Proteins GmhAGC and NGO1985 as Molecular Targets for Development of Novel Anti-gonorrhea Therapeutic Interventions

    Creator:
    Wierzbicki, Igor H.
    Abstract:
    The sexually transmitted disease gonorrhea, caused by the Gram-negative bacterium and obligate human pathogen Neisseria gonorrhoeae, remains a significant health and economic burden worldwide. In the absence of a protective vaccine, antimicrobial agents are the only pharmacological intervention for patients with gonorrhea. However, due to the remarkable ability of gonococcus...
    Resource Type:
    Dissertation

  • The Response to Sulforaphane in Metastatic Prostate Cancer Cells

    Creator:
    Watson, Gregory
    Abstract:
    Sulforaphane is an isothiocyanate derived from cruciferous vegetables and has been under investigation as a cancer chemopreventive agent for over two decades. The compound is well tolerated and has been shown to slow cancer progression in several different pre-clinical models of carcinogenesis, such as of the lung, breast and colon....
    Resource Type:
    Dissertation
    Full Text:
    . Rod Dashwood, Dr. Michael Freitag, Dr. Jean Hall, Dr. Siva Kolluri, and Dr. Dave Williams, for

  • Examining the Effects of High Vitamin E Diets on the Rodent Skeleton

    Creator:
    Kasper, Katherine G.
    Abstract:
    The primary goal of my study was to evaluate the effects of high dietary vitamin E on the rodent skeleton. The outcomes from my study assess the impact of high intakes of vitamin E and increased concentrations of its metabolite, carboxy ethyl hydroxy chromanol (CEHC), on bone turnover and skeletal...
    Resource Type:
    Masters Thesis
    Full Text:
    appreciative of my committee members, Urszula Iwaniec, Russ Turner, and Siva Kolluri, for their interest in

  • Evaluation of peptide phosphorodiamidate morpholino oligomers as a novel antibiotic therapy

    Creator:
    Kaller, Margo
    Abstract:
    Peptide-phosphorodiamidate morpholino oligomers (PPMOs) are synthetic DNA mimics that bind and silence gene targets. Through designing PPMOs that silence essential or resistance genes in pathogens, these antisense oligomers could be utilized as novel antimicrobials. Towards this end, my thesis employed minimum inhibitory concentration assays (MICs) to identify PPMOs capable of...
    Resource Type:
    Masters Thesis
    Full Text:
    as well! Dr. Siva Kolluri’s class on molecular therapeutics was a formative experience for my

  • Antimicrobial peptide regulation by small molecules in humans and other primates

    Creator:
    Sinnott, Brian D.
    Abstract:
    Antimicrobial peptides (AMPs) play an important role in the innate immune system. Determining the pathways by which these proteins are regulated allows for modulation of their expression for better health. Two families of antimicrobial peptides have been studied in humans: cathelicidins and defensins. There is a single cathelicidin in humans...
    Resource Type:
    Masters Thesis

  • Harnessing Heterogeneity in Human Gut Microbiome Data

    Creator:
    Tataru, Christine
    Abstract:
    The focus of this thesis is to design, characterize, and apply novel computational methods and molecular systems to interrogate heterogeneous human gut microbiome-related phenomena. In Chapter 2, I design, implement, and characterize a method for embedding co-occurrence patterns derived from massive 16s amplicon datasets. I use this method to 1....
    Resource Type:
    Dissertation
    Full Text:
    relationships be- tween microbial taxa or genes that may imply function. Represent relationships be- tween k