Turkey is an agricultural country where exchange and shipping of goods has been gravely hampered in the past by lack of highways. The railroads have large expanses of land between them, and highway construction in the past has been limited to strategic roads and connections of cities to railways. Unless...
Mandelalide A has attracted considerable interest from the synthetic community due to its intriguing structure and important cytotoxic activity. Madeirolide A, a structurally related macrolide, shows promising antifungal activity but no appreciable anticancer activity. This dissertation describes synthetic studies toward mandelalide A, madeirolide A and their hybrid structures.
Part I...
Recently, feminist scholars have begun to question the traditional telling of the history of rhetoric. Dissatisfied with a history which is told in terms of privileged, white males to the exclusion of all other voices, these scholars have worked to recover "lost" female rhetoricians and have begun critically rereading the...
I led a collaborative project involving a search for an evidence of a gravitational wave background (GWB) with all the spatial correlations allowed by general metric theories of gravity using NANOGrav’s 12.5 year data set. The search found no substantial evidence in favor of the existence of such correlations.
The...
Mouse embryo cells cultured in vitro in serum-supplemented media undergo growth
crisis, resulting in the loss of genomically normal cells prior to the appearance of
established, aneuploid cell lines. I used the technique of serum-free cell culture to develop
a serum-free mouse embryo (SFME) cell line in which serum was...
Recent changes in the historiography of American Transcendentalism
have inspired a reappraisal of the relationship between the Transcendentalist
movement in New England and the pietistic wing of the Unitarian church. This
thesis explores this reappraisal through a close reading of selected writings by
Henry Ware Jr. in juxtaposition to the...
My investigations of the natural products of marine algae have resulted in
the discovery of several new secondary metabolites. Bioassay-guided
fractionation led to the isolation of these new compounds and spectroscopic
analysis was utilized in their structural characterization.
Two new and potent antimitotic metabolites, curacins B and C, were
isolated...
Rapid rates of biodiversity loss have supported the notion that Earth is experiencing a sixth major extinction event. The causes of worldwide biodiversity loss are multifaceted and context dependent. One of the most prominent groups experiencing population declines and extinctions are amphibians. Several pathogens and their associated diseases are especially...
