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Ligand binding to the muscarinic receptor : equilibrium and kinetic studies

Creator:: Hirschberg, Birgit T.
Resource Type:: Dissertation
Full Text:: Philosophy in Biochemistry and Biophysics presented on November 11. 1993 Title: Ligand Binding to the

Active site studies and design of ligands for affinity column separation of 2,5-dihydroxyacetanilide epoxidase (DHAE) I and II

Creator:: Allen, Scott E.
Abstract:: A series of compounds, 7-8 and 20-25, were tested as competitive inhibitors of 2,5-dihydroxyacetanilide epoxidase I (DHAE I) and DHAE II. A Hammett plot was constructed for each enzyme to determine the effect of electron density on inhibition. DHAE I gave a linear, highly correlated plot (r²=0.91) that signifies the...
Resource Type:: Dissertation
Full Text:: interactions on ligand binding in the steroid and fatty acid binding sites in CEase. Values were obtained for

Effects of small molecule ligands on the conformational dynamics of the Farnesoid X Receptor ligand binding domain (FXR-LBD)

Creator:: Yang, Liping
Abstract:: The Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily of transcription factors that plays a key role in the regulation of bile acids, lipid and glucose metabolisms. The regulative function of FXR is governed by conformational changes of the ligand binding domain (LBD) upon ligand binding....
Resource Type:: Dissertation
Full Text:: of Small Molecule Ligands on the Conformational Dynamics of the Farnesoid X Receptor Ligand Binding

Molecular mechanisms of peroxisome proliferator-activated receptor signaling

Creator:: Dowell, Paul T.
Abstract:: Peroxisome proliferator-activated receptors (PPARs) are members of a large group of ligand-regulated transcription factors that includes nuclear receptors for steroid and thyroid hormones, retinoids and vitamin D₃. Synthetic fibrates and thiazolidinediones that bind to and activate PPARs are used efficaciously in humans to remedy hypertriglyceridemia and non-insulin dependent diabetes mellitus,...
Resource Type:: Dissertation
Full Text:: . Ligand binding domain = LBD. 5 protein interaction surface. The E region is a multifunctional

Characterization and photoaffinity labeling of the muscarinic acetylcholine receptor

Creator:: Cremo, Christine
Resource Type:: Dissertation
Full Text:: had been recently characterized with respect to mecha- nism of ligand binding (Schimerlik and Searles

Biophysical basis of macromolecular assembly in the dynein cargo attachment complex

Creator:: Hall, Justin Daniel
Abstract:: Cytoplasmic dynein is an ATP-dependent, microtubule-based molecular motor involved in the positioning and trafficking of cellular cargo. The cargo binding sub-domain of dynein contains the natively disordered intermediate chain (IC) and the homodimeric light chains (Tctex1, LC8 and LC7). The structure and stoichiometry of this complex, how the light chains...
Resource Type:: Dissertation
Full Text:: , suggesting that the degree of ordering upon binding is ligand dependent. The reduced complexity of motion

Site-specific labeling of the cardiac glycoside receptor Na⁺,K⁺-ATPase : synthesis of a C-17 side group photoaffinity label ; Relationship of cardioactive steroid structure and conformation to biological activity

Creator:: Deffo, Tamboue Esaie
Abstract:: In an effort to isolate and characterize cardiac glycosides C-17 binding site(s), we have synthesized different affinity and photoaffinity C-17 side chain probes. These probes were screened for their ability to inhibit Na⁺,K⁺-ATPase enzyme, a pharmacological receptor of cardiac glycosides. The enzyme was isolated from hog kidney. Screening of these...
Resource Type:: Dissertation
Full Text:: of the receptor site, itself. In biology, the proteins are the obvious ligand-binding molecules and

Ligand selective regulation of cell growth by the Ah receptor through activation of TGF-beta signaling, Ligand selective regulation of cell growth by the Ah receptor through activation of TGFβ signaling

Creator:: Koch, Daniel C.
Abstract:: The Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and member of the basic helix-loop-helix Per/ARNT/Sim (bHLH/PAS) family of chemosensors and developmental regulators. As a member of the PAS domain family of transcription factors responsive to exogenous signals, the AhR exerts influence on many processes relating to cellular fate....
Resource Type:: Dissertation
Full Text:: AhR ligand-binding domain (LBD) for virtual ligand screening (VLS) of small molecule libraries. This

Three Sites are Better than One : Exploring Multivalency in LC8 Binding Partners

Creator:: Clark, Sarah A.
Abstract:: Hub proteins bind a large number of partners to facilitate structural changes and downstream protein interactions. LC8, a highly conserved protein homodimer, is a unique hub that regulates the activity of proteins in a wide range of cellular processes by binding to intrinsically disordered regions. With many of these systems,...
Resource Type:: Dissertation
Full Text:: . ........................................................................................... 6 Figure 1.4. Structural basis of ligand binding to LC8

ScholarsArchive@OSU

Ligand binding to the muscarinic receptor : equilibrium and kinetic studies

Active site studies and design of ligands for affinity column separation of 2,5-dihydroxyacetanilide epoxidase (DHAE) I and II

Effects of small molecule ligands on the conformational dynamics of the Farnesoid X Receptor ligand binding domain (FXR-LBD)

Molecular mechanisms of peroxisome proliferator-activated receptor signaling

Characterization and photoaffinity labeling of the muscarinic acetylcholine receptor

Biophysical basis of macromolecular assembly in the dynein cargo attachment complex

Site-specific labeling of the cardiac glycoside receptor Na⁺,K⁺-ATPase : synthesis of a C-17 side group photoaffinity label ; Relationship of cardioactive steroid structure and conformation to biological activity

Ligand selective regulation of cell growth by the Ah receptor through activation of TGF-beta signaling, Ligand selective regulation of cell growth by the Ah receptor through activation of TGFβ signaling

Three Sites are Better than One : Exploring Multivalency in LC8 Binding Partners

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