The two major objectives of this thesis are: (1) demonstrating and
applying optimal design theory by developing an optimal sampling-time
strategy for parameter estimation in stochastic one compartment models,
and (2) examining in depth the extended least squares (ELS) method of
estimating population pharmacokinetic parameters.
The nonlinear weighted least squares...
This study centered upon two objectives. First, to demonstrate and apply a statistical method, the transfer function, and to test its usefulness in regional economic modeling and regional impact ana1ysis; and second, to obtain a better understanding of the causal relationships among total employment, government employment, lumber and wood products...
In this paper, we present the design, fabrication and characterization of a traveling
wave directional coupler modulator based on electro-optic polymer, which is able to provide
both high linearity and broad bandwidth. The high linearity is realized by introducing Δβ-reversal technique in the two-domain directional coupler. A travelling wave electrode...
We demonstrate a four-channel on-chip true-time-delay module based on a photonic crystal waveguide array. Using the photonic crystal taper to minimize the coupling loss, the delay lines with 1-3 mm long photonic crystal waveguides can operate up to a group index n(g) similar to ~23 without significant loss. The large...
We experimentally demonstrate highly efficient coupling into a slow light slotted photonic crystal waveguide. With optical mode converters and group index tapers that provide good optical mode matching and impedance matching, a nearly flat transmission over the entire guided mode spectrum of 68.8 nm range with 2.4 dB minimum insertion...
Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically,...