Incorporation of nanoparticles (NPs) into consumer products is on the rise and human exposure to NPs is unavoidable. Currently, there is insufficient data to assess the safety of nanoparticles. I conducted a series of five studies using the zebrafish model to determine which NP components (i.e., core material or surface...
Benzo[a]pyrene (B[a]P) is a common environmental pollutant produced from the incomplete combustion of organic matter, such as fossil fuel emissions. In vertebrates, B[a]P exposure is associated with hyperactivity, though the underlying mechanisms driving this effect are undescribed. Mounting evidence indicates that the gut microbiome, which is the diverse community of...
Objectives: Nitrate, found abundantly in green leafy vegetables, may improve exercise performance by increasing the availability and utilization of metabolic fuels that require less oxygen for energy production. However, it is not known if this performance effect occurs at the peak exercise intensity. We hypothesize that supplemental nitrate treatment will...
Graphene and its derivatives are two-dimensional hexagonal lattices that possess desirable physicochemical properties leading to an ever-expanding list of industrial and biomedical uses. Graphene oxides (GOs) are becoming a popular graphene alternative and while there have been human safety studies, investigations of developmental toxicity are lacking. The use of distinct...
As engineered nanomaterials (ENM) become more common in consumer products, it is crucial to rapidly assess toxicity of unique ENM. Previous studies rarely focused on standardizing nanotoxicity testing, leading to inconsistent and irreproducible results. This study characterized a variety of ENM of different size, shape, core type, and surface charge...
Per- and polyfluoroalkyl substances (PFAS) are contaminants of concern because they do not readily degrade in the environment. Some in vivo studies report that PFAS alter neurological development and are carcinogenic. Perfluorohexanesulfonamide (FHxSA) and 6:2 fluorotelomer sulfonate (6:2 FTS) are two PFASs, which are often detected in drinking water sources....
Per- and polyfluoroalkyl substances (PFAS) are a group of anthropogenic compounds that are used ubiquitously in different industrial fields. However, concerns regarding the potential health impacts of PFAS, including perfluoroalkyl carboxylic acids
(PFCAs) and perfluoroalkyl sulfonates (PFSAs), has raised stakeholder interest regarding continued use of PFAS. Analytical methods for PFAS...
The use of zebrafish in behavioral neuroscience is rapidly growing. Zebrafish can be assessed for alterations in multiple behavioral endpoints, creating opportunities to use this powerful model to identify chemicals that alter behavioral phenotypes. To evaluate the utility of zebrafish for neurotoxicity research, we designed custom instrumentation to evaluate numerous...
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: Using the zebrafish to
evaluate neurobehavioral phenotypes
Abraham Garcia, LisaTruong (PhD), Eric
The use of zebrafish in behavioral neuroscience is rapidly growing. Zebrafish can be assessed for alterations in multiple behavioral endpoints, creating opportunities to use this powerful model to identify chemicals that alter behavioral phenotypes. To evaluate the utility of zebrafish for neurotoxicity research, we designed custom instrumentation to evaluate numerous...
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Acknowledgements
Tanguay Lab
Dr. Robert Tanguay
Dr. Michael Simonich
Dr. LisaTruong
Dr. Andrea Knecht
Dr. Maret
The use of zebrafish in behavioral neuroscience is rapidly growing. Zebrafish can be assessed for alterations in multiple behavioral endpoints, creating opportunities to use this powerful model to identify chemicals that alter behavioral phenotypes. To evaluate the utility of zebrafish for neurotoxicity research, we designed custom instrumentation to evaluate numerous...
Full Text:
and 10-hour dark photoperiods (Truong et
al.). Embryos were collected from 100 gallon massive embryo