Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of excess neutral lipids within the parenchymal cells of the liver. The primary etiology is diet-induced and most often exists as a comorbidity with obesity, metabolic syndrome, and/or Type 2 Diabetes. The development of excess liver lipid can be self-limiting...
Aging, obesity and increased waist circumference (WC) increases risk for metabolic syndrome (MetS). MetS is a cluster of symptoms (elevated WC, triglycerides, blood pressure, fasting glucose, and decreased high-density lipoprotein cholesterol [HDL-C]) increasing risk for chronic disease. Low-energy dense (LED) diets, emphasizing whole food eating patterns, have not been examined...
Perinatal growth restriction programs higher risk for chronic disease during adulthood via morphological and physiological changes in organ systems. Perinatal growth restriction is highly correlated with a decreased nephron number, altered renal function and subsequent hypertension. I hypothesize that such renal maladaptations result in altered pharmacologic patterns for life. Pregnant...