Index Catalog // ScholarsArchive@OSU

Bioactive Microbial Natural Products from Unique Indonesian Black Water Ecosystems

Creator:: Sheng, Yan
Abstract:: The discovery of new antibiotics reached its peak during the golden era of antibiotics in the mid 20th century and continued to thrive until the 1980s. However, after more than 50 years of fruitful exploration and exploitation of microbial natural products the discovery rate of new antibiotics has dropped drastically...
Resource Type:: Dissertation
Full Text:: development history. Over the time period of 1940 and 2010, 85 out of 175 small molecules (~48.6%) approved

Synthetic studies on the macrolide antibiotic rutamycin B

Creator:: Wang, Shan
Resource Type:: Dissertation
Full Text:: Synthetic studies on the macrolide antibiotic rutamycin B AN

Part I: Total synthesis of marine macrolide amphidinolide F and synthetic studies toward amphidinolide C; Part II: Computational study on proline sulfonamide-catalyzed aldol reaction

Creator:: Mahapatra, Subham
Abstract:: More than 30 members of the diverse amphidinolide family of biologically active macrolides have been isolated over last three decades. From this family, amphidinolides C and F stand among the most complex and densely functionalized affiliates. Recently, we have accomplished the first total synthesis of amphidinolide F. The all-carbon framework...
Resource Type:: Dissertation
Full Text:: Title: Part I: Total Synthesis of Marine Macrolide Amphidinolide F and Synthetic Studies Toward

The synthesis of macrolactones from [omega]-hydroxyacyl xanthates

Creator:: Akella, Annapoorna
Resource Type:: Masters Thesis
Full Text:: placed on the ring, and are often further elaborated with one to three glycoside units. A macrolide is

Studies toward the total synthesis of sanglifehrin A

Creator:: Suttisintong, Khomson
Abstract:: Studies toward synthesis of subunits of sanglifehrin A, an immunosuppressant featuring a highly substituted [5,5]-spirolactam moiety as well as a 22-membered macrocycle are described. The macrolactone contains a peptidic backbone characterized by an unusual [beta]-substituted (S)-piperazic acid and (S)-m-hydroxyphenylalanine units. These studies resulted in the synthesis of advanced intermediate 358...
Resource Type:: Dissertation
Full Text:: Macrolide Analogue of SFA …………46 2.8 References………………………………………………………………….48 3. SYNTHESIS OF THE C13-C19

Enantioselective Total Syntheses of Quinolizidine Lycopodium Alkaloid Cermizine D and Cytotoxic Marine Macrolide Mandelalide A

Creator:: Veerasamy, Nagarathanam
Abstract:: The enantioselective total synthesis of quinolizidine-containing natural product cermizine D and formal syntheses of senepodine G and cermizine C has been achieved. These natural products are members of the lycopodium alkaloids, which have attracted significant attention due to their exciting biological activities and the diverse structural scaffolds. Key steps in...
Resource Type:: Dissertation
Full Text:: Lycopodium Alkaloid Cermizine D and Cytotoxic Marine Macrolide Mandelalide A. Abstract approved

Mandelalides as Potent Mitochondrial ATP Synthase Inhibitors : From Discovery of New Analogs to Function-Oriented Synthetic Studies

Creator:: Nazari, Mohamad
Abstract:: Our quest for pharmaceutically important marine natural products led to re-isolation of known mandelalides A-D and identification of new congeners E-L from re-collected South African Lissoclinum tunicate specimens. Mandelalides A, B, and L were characterized as selective cancer cell toxins, with an unusual activity profile influenced by their glycosylation /...
Resource Type:: Dissertation
Full Text:: .....................................................................................................................44! New Mandelalides Expand a Macrolide Series of Mitochondrial Inhibitors ....................44

Biosynthesis and Rational Design of Novel Pactamycin Analogs

Creator:: Abugrain, Mostafa E.
Abstract:: Pactamycin, a potent antitumor antibiotic produced by the soil bacterium Streptomycespactum, is a structurally unique aminocyclopentitol-containing natural product. Itconsists of a highly functionalized cyclopentitol core unit, two aromatic rings [3-aminoacetophenone (3AAP) and 6-methylsalicylic acid (6MSA)], and a 1,1-dimethylurea moiety. Despite its potent biological activity, the development of thisantibiotic was hampered...
Resource Type:: Dissertation
Full Text:: Mahmud Pactamycin, a potent antitumor antibiotic produced by the soil bacterium Streptomyces

Advanced studies on cyclic amino acids in neurological signaling and peptide antibiotics

Creator:: Blanchard, David, L.
Abstract:: L-pipecolic acid (L-PA) is the higher homolog of proline. It occurs naturally in many organisms, including primates, as an intermediate in lysine degradation. The pathway by which lysine is converted into L-pipecolic acid employs the enzyme Lpipecolate oxidase (L-PO), and appears to be tissue specific to the central nervous system...
Resource Type:: Dissertation
Full Text:: of action for L-PO may be useful in the development of neuromodulation. This thesis describes

Evaluation of peptide phosphorodiamidate morpholino oligomers as a novel antibiotic therapy

Creator:: Kaller, Margo
Abstract:: Peptide-phosphorodiamidate morpholino oligomers (PPMOs) are synthetic DNA mimics that bind and silence gene targets. Through designing PPMOs that silence essential or resistance genes in pathogens, these antisense oligomers could be utilized as novel antimicrobials. Towards this end, my thesis employed minimum inhibitory concentration assays (MICs) to identify PPMOs capable of...
Resource Type:: Masters Thesis
Full Text:: Generations of antibiotic development are predicated upon minor changes to essentially similar structures

ScholarsArchive@OSU

Bioactive Microbial Natural Products from Unique Indonesian Black Water Ecosystems

Synthetic studies on the macrolide antibiotic rutamycin B

Part I: Total synthesis of marine macrolide amphidinolide F and synthetic studies toward amphidinolide C; Part II: Computational study on proline sulfonamide-catalyzed aldol reaction

The synthesis of macrolactones from [omega]-hydroxyacyl xanthates

Studies toward the total synthesis of sanglifehrin A

Enantioselective Total Syntheses of Quinolizidine Lycopodium Alkaloid Cermizine D and Cytotoxic Marine Macrolide Mandelalide A

Mandelalides as Potent Mitochondrial ATP Synthase Inhibitors : From Discovery of New Analogs to Function-Oriented Synthetic Studies

Biosynthesis and Rational Design of Novel Pactamycin Analogs

Advanced studies on cyclic amino acids in neurological signaling and peptide antibiotics

Evaluation of peptide phosphorodiamidate morpholino oligomers as a novel antibiotic therapy

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