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  • Investigating the Role of the MutLα Endonuclease

    Creator:
    Mankaney, Gautam Naresh
    Abstract:
    Lynch individuals have a predisposition to developing colorectal and other cancers due to inherited defects in their mismatch repair (MMR) system. Although mutations in MMR have been directly implicated in Lynch Syndrome, the precise mechanism(s) of MMR functions have yet to be elucidated. One essential complex, MutL (a dimer of...
    Resource Type:
    Honors College Thesis
    Full Text:
    ABSTRACT OF THE THESIS OF Gautam Naresh Mankaney for the degree of Honors Baccalaureate of Science in

  • Generation of proof of concept molecules neutralizing monoclonal antibodies to IL17Cm

    Creator:
    Calhoun, Drew W.
    Abstract:
    Inflammation is one of the first, most important responses of the immune system when presented with infection and is mediated primarily by eicosanoids and cytokines. The goal of this research was to generate monoclonal antibodies against murine IL17C, a poorly characterized cytokine involved in inflammation and linked to inflammatory conditions....
    Resource Type:
    Honors College Thesis
    Full Text:
    Gautam Naresh Mankaney Generation of Proof of Concept Molecules: Neutralizing Monoclonal Antibodies to

  • A Novel Approach to the Biochemical Analysis of Variants in the Essential DNA Mismatch Repair Protein MLH1

    Creator:
    Nguyen, Andrew
    Abstract:
    Genomic integrity is crucial for the viability and function of a cell. One key pathway that acts to maintain genomic integrity is DNA mismatch repair (MMR). MMR acts to correct base pair mismatches hat have escaped proofreading during DNA replication. The process of MMR is dependent on the protein heterodimer...
    Resource Type:
    Honors College Thesis
    Full Text:
    Karen Hippchen and Marie Strand for your support and encouragement. Special thanks goes to Gautam

  • Phenotypic analysis of human MLH1 variants for DNA mismatch repair

    Creator:
    Hippchen, Karen Jean
    Abstract:
    DNA mismatch repair (MMR) is an evolutionarily conserved process used by cells to decrease mutation rates, thereby increasing genetic stability and reducing cancer risk. Germline mutations in the MMR gene MLH1 have been identified in Lynch Syndrome patients, and in many cases are suspected but not confirmed as causative for...
    Resource Type:
    Masters Thesis
    Full Text:
    Nelson, Gautam Mankaney, Andy Nguyen and Marie Strand for their insightful discussions, humor

  • Biochemistry Free and Easy

    Creator:
    Ahern, Kevin and Rajagopal, Indira
    Resource Type:
    Book
    Full Text:
    Pham Emilie Servin Eric Brooks Erika Snow Dr. Derek Youngblood Dr. Gautam Mankaney Georgi Mitev