Index Catalog // ScholarsArchive@OSU

Displacement-based fluorescent microRNA biosensors : design principles and analytical metrics

Creator:: Larkey, Nicholas E.
Abstract:: One post-transcriptional mechanism that regulates the progression of cancer and other diseases involves small 22-23 nucleotide sequences called microRNA (miR). Early detection of small changes in concentration of these biomarkers holds potential to diagnose diseases at their earliest stages. Use of current nucleic-acid based biosensors, like molecular beacons, for in...
Resource Type:: Dissertation
Full Text:: Ho, Dr. Molly Megraw, and Dr. Shelley Su. A big ‘thank you’ goes out to all the wonderful people I

Disturbances in a marine bacterioplankton system drive community assembly towards niche-based processes

Creator:: Vergin, Kevin L.
Abstract:: Over 100 monthly bacterioplankton DNA samples, from each of the surface and 200 m depths at the Bermuda Atlantic Time-series Study (BATS) site, were analyzed for community assembly processes. Correlation networks, filtered for potential autocorrelation artifacts, were constructed for each depth. Network characteristics for the two depths were remarkably similar...
Resource Type:: Masters Thesis
Full Text:: after the missing sample(s). Simulations demonstrate that non-normality in the residuals of only one

Variant Annotation

Creator:: He, Jun
Abstract:: With the development of technologies in genome sequencing and variant detection, a huge number of variants are detected. To further analyze the variants, it requires an efficient tool to annotate the functional effect of variants. This project managed to develop an efficient program to annotate the functional effect of variants...
Resource Type:: Capstone Project
Full Text:: . Prasad Tadepalli, Prof. Molly Megraw for their insights, suggestions and their time for my final exam

Investigation of the Patterns and Transcriptional Regulators from Gene Expression Profiles of Adult Murine Soleus and Tibialis Anterior Skeletal Muscles

Creator:: Alto, Sarah I.
Abstract:: Skeletal muscles provide several functions, including, yet not limited to, voluntary body movement and locomotion, posture and body position, and soft tissue support. Skeletal muscles also play a role in metabolism, requiring energy to facilitate contraction. Each skeletal muscle serves a different purpose despite seeming to perform the same task....
Resource Type:: Dissertation
Full Text:: served on my graduate committee: To my minor advisor, Dr. Molly Megraw, for all of her support and

Multiple Instance Learning for Histopathological Image Classification

Creator:: Lai, Phung
Abstract:: In histopathological image analysis, image classification as well as pattern detection play a crucial role in the diagnosis and treatment process since the goal is to not only differentiate cancer types but also identify cancerous manifestations. Fully supervised learning strategies tend to address these problems using manually annotated cancerous regions...
Resource Type:: Capstone Project
Full Text:: . Xiao Fu, and Dr. Molly Megraw for their attendance and advice in my defense. I would also like to

Studies on the ecological functions of the antidiabetic drugs acarbose

Creator:: Tanoeyadi, Samuel
Abstract:: Natural products (a.k.a. secondary metabolites) are produced by living organisms that are not essential for their growth, development, or reproduction, but may play a role in their survival or adaptability in nature. Many secondary metabolites isolated from plants and microbes have found use as molecular probes, drug leads, or medicine...
Resource Type:: Masters Thesis
Full Text:: . Jane Ishmael, and Dr. Molly Megraw, for all of their time, expertise, and readiness in serving my

Using the Microbial Tree of Life to Describe Mammalian Health and Disease

Creator:: Arnold, Holly Kristin
Abstract:: The past decade of research has potentiated a revolution in our understanding of mammalian health and evolution by revealing that the gut microbiome plays a central role in mammalian physiology. Our ability to unlock this potential hinges upon the identification of specific groups of gut microbes that elicit effects on...
Resource Type:: Dissertation
Full Text:: within a medical microbiology context, and Dr. Molly Megraw who contributed to my understanding of the

Insights into Novel Non-Fumigant Nematicides: Physiological and Cellular Responses of Meloidogyne Incognita and Other Plant-Parasitic Nematodes

Creator:: Wram, Catherine L.
Abstract:: Plant-parasitic nematodes (PPN) pose a severe threat to crop production with the economic losses due to nematode parasitism in excessive of US$ 80 billion each year. Meloidogyne incognita, a globally distributed pest with a diverse host range, contributes significantly to this economic loss. The most reliable way to manage PPN...
Resource Type:: Dissertation
Full Text:: Denver, Cynthia Gleason, Molly Megraw, and Gail Langellotto. I greatly appreciate their service on my

Seeing Genes: Multiscale Phenotyping Reveals Gene Functions in Maize Pollen

Creator:: Warman, Cedar D.
Abstract:: Plant sexual reproduction requires a broad array of molecular mechanisms to proceed successfully. Some of these mechanisms are well-studied, but our knowledge of them as a whole is fundamentally incomplete. Pollen tube growth is a key part of this process, facilitating the delivery of the sperm cells to the female...
Resource Type:: Dissertation
Full Text:: approaches first require digital representations of the phenotype(s) of interest, generally in the form of

Identification and Functional Characterization of Genes that Regulate Biomass Production, Floral Development, and Leaf Senescence in Populus Species using Genetic Engineering and Bioinformatics Tools

Creator:: Lu, Haiwei
Abstract:: This dissertation is comprised of four studies on different elements of Populus biotechnology and genomic science: 1) growth improvement by recombinant DNA (rDNA) modification of gibberellin (GA) metabolism; 2) gene editing using zinc-finger nucleases (ZFNs); 3) induction of floral sterility by RNA interference (RNAi) of AGAMOUS (AG) gene homologs; and...
Resource Type:: Dissertation
Full Text:: grateful to my committee members, Amy Klocko, Molly Megraw, John Fowler, and Robert Thompson, for their

ScholarsArchive@OSU

Displacement-based fluorescent microRNA biosensors : design principles and analytical metrics

Disturbances in a marine bacterioplankton system drive community assembly towards niche-based processes

Variant Annotation

Investigation of the Patterns and Transcriptional Regulators from Gene Expression Profiles of Adult Murine Soleus and Tibialis Anterior Skeletal Muscles

Multiple Instance Learning for Histopathological Image Classification

Studies on the ecological functions of the antidiabetic drugs acarbose

Using the Microbial Tree of Life to Describe Mammalian Health and Disease

Insights into Novel Non-Fumigant Nematicides: Physiological and Cellular Responses of Meloidogyne Incognita and Other Plant-Parasitic Nematodes

Seeing Genes: Multiscale Phenotyping Reveals Gene Functions in Maize Pollen

Identification and Functional Characterization of Genes that Regulate Biomass Production, Floral Development, and Leaf Senescence in Populus Species using Genetic Engineering and Bioinformatics Tools

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