Phosphorodiamidate morpholino oligomers (PMOs) are novel antisense drugs in the early stages
of development. These synthetic DNA mimics contain the same bases found in DNA and anneal
to RNA in a complementary fashion. PMOs have been designed that target genes responsible for
producing essential proteins in organisms such as Escherichia...
Cell-to-cell communication by chemical signals, termed quorum sensing (QS), is a common regulatory scheme in the microbial world. Pseudomonas aeruginosa¸ an opportunistic pathogen of burn wounds and cystic fibrosis lungs, uses QS to control the expression of hundreds of genes, particularly those necessary for population level benefits such as biofilm...
High-throughput culturing (HTC) consisting of extinction culturing in autoclaved seawater has led to the isolation and characterization of many novel strains of oligotrophic marine bacteria. Strain HTCC 2207 was isolated from the Oregon coast by the HTC method. Phylogenetic analysis based on 16S rRNA gene sequence showed that this strain...
Studies on prison contracting have typically focused on the privatization of entire facilities and carceral services offered to inmates. There has been limited research, however, as to how political ideology influences the extent to which state prisons contract out health care services. There also appears to be a need for...
Many bacteria possess cell density-dependent quorum-sensing (QS) systems that often regulate cooperative secretions involved
in host-microbe or microbe-microbe interactions. These secretions, or “public goods,” are frequently coregulated by stress and
starvation responses. Here we provide a physiological rationale for such regulatory complexity in the opportunistic pathogen
Pseudomonas aeruginosa. Using minimal-medium...
Full Text:
Goods in Pseudomonas aeruginosa
BrettMellbye, Martin Schuster
Department of Microbiology and
Visible homelessness is a complex and enduring issue that remains salient in policymaking and political realms. In response to homeless individuals living their lives in public spaces, many cities have enacted civility codes or laws that address quality of life concerns in an attempt to remove visible signs of homelessness...
Understanding the ecological role of Pacific oyster aquaculture (Crassostrea gigas) and eelgrass (Zostera marina L.) as important habitats in US Pacific Northwest estuaries is critical for management and regulatory decisions. The oyster aquaculture industry is currently restricted by regulations concerning impacts of their activities on Z. marina. This seagrass is...
A great deal of research has documented racial disparities in imprisonment rates in the United States, but little work has been done to understand the process by which inmates are assigned to individual correctional facilities. This article extends research on racial disparities in imprisonment rates to consider racial disparities in...
Hybrids with abnormal development were obtained when particular
genotypes of Phaseolus vulgaris L. were crossed. The phenotypic
aberrations of the F₁s included retarded growth, chlorosis of the
trifoliate leaves and the formation of adventitious roots on the
hypocotyls. The expression of the abnormalities was dependent on the
temperature. At high...
The overall focus of this thesis is on the distribution of specific lipids and membrane proteins of the external and internal membranes of plant cells, in the context of the roles that those lipids and proteins may play in microbe-plant interactions. The work includes the development of several new tools,...