Peptide phosphorodiamidate morpholino oligomers (PPMO) are synthetic DNA mimics that bind complementary RNA and inhibit bacterial gene expression. (RFF)₃RXB- AcpP PPMO (R, arginine; F, phenylalanine; X, 6-aminohexanoic acid; B, β-alanine) is complementary to 11 bases of the essential gene acpP (encodes acyl carrier protein). The MIC of (RFF)₃RXB-AcpP was 2.5...
Two different types of Phosphorodiamidate Morpholino Oligomers (PMOs) were used to
inhibit growth in pure cultures of Salmonella enterica serovar typhimurium and in mouse
macrophages infected with S. typhimurium. Both PMOs were 11 bases long and
complementary to bases 6-16 of acyl carrier protein mRNA. A membrane-penetrating
peptide, (RXR)4XB, was...