This dissertation describes how to apply pharmacokinetic simulations and modeling in a clinical setting to monitor and adjust drug dosing in special patient populations. Pharmacokinetic simulations were used to investigate efficacy and risk of drug toxicity of a new dosing regimen for aminoglycoside antibiotics when administered to renal failure patients....
Common estimators of the mean g(θ) = Jx dFθ(x) in skewed distribution models may be sensitive to contamination by a few large observations. It is then desirable to consider robust estimators g(θ) .The approach of Hampel (1968), who defines an estimator θ for the parameter vector θ to be optimal...
Finding renewable sources of agricultural fertilizer will be necessary to ensure a stable food supply for future generations. Phosphorus is of particular concern, since mining phosphate rock is the main source and reserves are forecasted to deplete in the next 50 – 200 years. Human urine contains substantial amounts of...
Productivity Interfirm Comparison (PIC) is a simple
method used to improve productivity at the firm level,
where a number of firms operate in the same product line so
that performance information on the firms can be compiled
and compared. This results in identifying potential areas
for improvement or exploitation. The...
This thesis experimentally determines the feasibility to creating C4 to C10 hydrocarbons from CO2, CO, H2, H2O and CH4. This is done in two steps, the initial step is the formation of ethylene through DC electrical glow discharge at ambient pressure while the second step is through temperature pulse controlled...
This thesis is an account of investigation on the natural products deriving from various marine algae and has resulted in the discovery of eleven novel bioactive metabolites. Isolation and characterization of these new molecules were carried out using different chromatographic techniques and by analyses of different spectroscopic data, respectively. Using...
Many substances in the plant kingdom and in man's diet occur
as glycosides. Recent studies have indicated that many glycosides
that are not mutagenic in tests such as the Salmonella/microsome
test become mutagenic upon hydrolysis of the glycosidic linkages.
The Salmonella/microsome test utilizes a liver homogenate to approximate
mammalian metabolism...
We tested a synthetic bacterio-opsin (bO) gene derived from Halobacterium halobium for its effect on disease resistance in transgenic poplar hybrids, and assessed a genetic system for controlling expression of this gene. In tobacco the bO gene caused necrotic lesions similar to an induced hypersensitive response (HR), increased levels of...
We isolated and characterized the expression of two genes from Populus
trichocarpa that are homologous to the TERMINAL FLOWER 1 (TFL1) gene from
the model annual plant Arabidopsis. In Arabidopsis, overexpression of the TFL1
gene extends the vegetative growth phase, and the homozygous mutant tfl1 allele
causes early flowering and...