Mycobacterium avium cause disseminated disease in immunocompromised people such as AIDS patients. Subsequent to crossing the intestinal epithelium, M. avium thrive within vacuoles in macrophages. The bacteria exhibit a different, more invasive, phenotype after being in macrophages compared to M. avium from laboratory conditions. We hypothesized that this intracellular phenotype...
Mycobacterium avium is a ubiquitous environmental organism found in both water and soil. It can cause disease in patients with previous pulmonary conditions, as well as immunosupressed patients, with the most prevalent being AIDS patients. Studies have indicated that passage through amoeba, a common environmental protozoa, increases virulence of M....
Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of Johne's disease, a chronic inflammatory bowel disease that affects ruminant populations worldwide. The characteristic stages of the disease make diagnosis difficult, resulting in silent transmission among animals in a herd for years before proper detection of the infection. The extensive...
Mycobacterium avium is an intracellular pathogen that is associated with disseminated
infection, especially in patients with acquired immunodeficiency syndrome (AIDS). It
appears that patients with AIDS acquire M. avium mostly through the intestinal tract,
and that bacteria enter the intestinal wall at the terminal ileum. Previous studies have
found that...
Mycobacterium avium subsp. hominissuis (MAH) is a pervasive environmental bacterium that can cause opportunistic infections in humans. Among the most robust and hardy members of the Mycobacterium genus, M. avium can persist and thrive in a range of challenging environments, including many which place it in direct contact with humans....
Environmental mycobacteria are important opportunistic pathogens for many hosts,
including humans, cattle, and fish. Two well-studied species are Mycobacterium
avium subsp. avium, a significant cause of disseminated bacterial disease in patients
with AIDS, and Mycobacterium avium subsp. paratuberculosis, the cause of Johne’s
disease in cattle. Many other species that are...
Cases of pulmonary diseases caused by Mycobacterium avium complex (MAC) have increased over the years and have become a major health concern in Europe, Asia, and the United States. MAC, comprised of M. avium species and M. intracellulare, are found everywhere in the environment: in water sources and the soil....
1,4-Dioxane (dioxane) is a probable human carcinogen and is often found comingled with chlorinated aliphatic hydrocarbon (CAH) contamination since dioxane is used as a stabilizer in CAH solutions. Dioxane is miscible in water, has a low K[subscript ow], low H[subscript cc], and is highly recalcitrant in the environment. The presence...
Mycobacterium avium subsp. paratuberculosis (MAP) is a cause of
Johne's disease (JD) in cattle and other ruminants. MAP infection in the bovine
host is not well characterized. It is assumed that crossing the bovine intestinal
mucosa is important for MAP to establish infection. MAP's ability to infect
bovine epithelial cells...
Mycobacterium avium is a ubiquitous environmental organism found in water and soil. It can cause disease in patients with pre-existing pulmonary conditions, immunocompromised patients with the most prevalent being AIDS patients, as well as apparently healthy people. Studies have indicated that, upon macrophage uptake, Al. avium prevents phagosome-lysosome fusion, thus...