BACKGROUND: Bisphenol A (BPA) is one of the most prevalent chemicals in daily-use materials; therefore, human exposure to BPA is ubiquitous. The estrogenicity of BPA is generally mediated by nuclear estrogen receptors (ERs). However, low concentrations of BPA stimulate seminoma cell proliferation by an uncertain mechanism that does not involve...
There is a great deal of evidence that altered sphingolipid metabolism is associated with fumonisin-induced
animal diseases including increased apoptotic and oncotic necrosis, and carcinogenesis in
rodent liver and kidney. The biochemical consequences of fumonisin disruption of sphingolipid
metabolism most likely to alter cell regulation are increased free sphingoid bases...
Background: There is increasing epidemiologic evidence that arsenic exposure in utero, even at low levels found throughout much of the world, is associated with adverse reproductive outcomes and may contribute to long-term health effects. Animal models, in vitro studies, and human cancer data suggest that arsenic may induce epigenetic alterations,...
BACKGROUND: Arsenic is an epigenetic toxicant and could influence fetal developmental programming.
OBJECTIVES: We evaluated the association between arsenic exposure and DNA methylation in maternal and umbilical cord leukocytes.
METHODS: Drinking-water and urine samples were collected when women were at <= 28 weeks gestation; the samples were analyzed for arsenic...
Background: When conducting research with American Indian tribes, informed consent beyond conventional institutional review board (IRB) review is needed because of the potential for adverse consequences at a community or governmental level that are unrecognized by academic researchers. Objectives: In this article, we review sovereignty, research ethics, and data-sharing considerations...
BACKGROUND: Chronic exposure to arsenic is associated with skin lesions. However, it is not known whether reducing arsenic exposure will improve skin lesions.
OBJECTIVE: We evaluated the association between reduced arsenic exposures and skin lesion recovery over time.
METHODS: A follow-up study of 550 individuals was conducted in 2009-2011 on...
Background: Arsenic is an immunotoxicant. Clinical reports observe the reactivation of varicella zoster virus (VZV) in people who have recovered from arsenic poisoning and in patients with acute promyelocytic leukemia that have been treated with arsenic trioxide. Objective: We evaluated the association between arsenic and the seroprevalence of VZV IgG...
The lead Renovation, Repair, and Painting Rule and
the Consumer Product Safety Improvement Act, both enacted in 2008, were
intended to protect children from exposure to lead by setting federal limits
on lead content. Neither of these federal actions, however, addresses a newly
recognized pathway of exposure to lead from...
Infection with the novel H10N8 virus in humans has raised concerns about its pandemic potential worldwide. We report the results of a cross-sectional study of avian influenza viruses (AIVs) in live poultry markets (LPMs) in Nanchang, China, after the first human case of H10N8 virus infection was reported in the...
In the 1961-62 academic year there were thirteen National
Defense Education Act Counseling and Guidance Training Institutes
established at institutions of higher education about the country.
The purpose of these institutes was to upgrade the counseling and
guidance skills of personnel employed as half-time counselors in
secondary schools. As a...