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Bioactive Microbial Natural Products from Unique Indonesian Black Water Ecosystems

Creator:: Sheng, Yan
Abstract:: The discovery of new antibiotics reached its peak during the golden era of antibiotics in the mid 20th century and continued to thrive until the 1980s. However, after more than 50 years of fruitful exploration and exploitation of microbial natural products the discovery rate of new antibiotics has dropped drastically...
Resource Type:: Dissertation
Full Text:: morphine, laid the basis of modern natural product 3 discovery. Since then, numerous important

Part I: Synthetic studies toward the southern portion of Azaspiracid-1; Part II: Total synthesis of amphidinolide B₁ and the proposed structure of amphidinolide B₂

Creator:: Lu, Liang
Abstract:: The structural architecture present in marine toxin azaspiracid - 20 stereocenters, 9 rings, 3 separated spirocenters - has attracted considerable synthetic attention. Our efforts toward the synthesis of azaspiracid have led to the completion of both C₁-C₂₆ northern and C₂₇-C₄₀ southern halves. Herein, the synthesis of southern FGHI ring system...
Resource Type:: Dissertation
Full Text:: . The new strategy afforded the natural product in 39 linear steps. 1.22 6 8 steps Me O H OTBDPS

Ascorbylation- the biological relevance of covalently bound ascorbic acid

Creator:: Kesinger, Nicholas G.
Abstract:: Ascorbic acid, or vitamin C, is well known as a co-factor for proline-hydroxylase and as an anti-oxidant. However, it is also capable of forming covalent bonds, particularly in the role of a nucleophile, henceforth termed 'ascorbylation'. The ascorbylation of electrophiles can occur under physiological conditions. Furthermore, there are a number...
Resource Type:: Dissertation
Full Text:: 5,6,7,8-tetrahydroxy-4-oxooctanal (THO). This same reaction scheme occurs with the natural product

Towards the Perfect Marriage Between Theory and Experiments in Drug Discovery and Synthesis : Insights into Structure Determination of Complex Natural Products and Mechanistic Understandings of Lactam Synthesis

Creator:: Snyder, Kevin M.
Abstract:: In this report, three studies are presented that aid in the development of drug discovery and their synthesis. In each, the importance of the marriage between computations and experiments is highlighted. Continued efforts in this vein are essential for future efforts towards improving human health. The first case study investigated...
Resource Type:: Masters Thesis
Full Text:: ] residues are inverted from L to D, was consistent with the spectra of the authentic natural product. In

Total Synthesis of Goniomitine : Development of Aminal and α-Amino Radicals in the Synthesis of Nitrogen-Rich Natural Products

Creator:: Vellucci, Jessica K.
Abstract:: Aminal radical intermediates were generated by the method of radical translocation and reacted in C-C bond forming reactions with electronically deficient alkenes (Schiedler et al. Org. Lett. 2012, 14, 6092). Aminal radical intermediates can participate in inter- and intra-molecular reactions using both Bu3SnH and (TMS)₃SiH as hydride donors. Carbon–carbon bonds...
Resource Type:: Dissertation
Full Text:: quaternary stereocenter of the natural product. Bromination followed by elimination provided the vinyl

Conformationally chiral diphenylethers and the enantioselective Ullmann etherification

Creator:: Salih, M. Quamar
Abstract:: Since the discovery of molecular chirality in 1848, this notion has had a substantial impact on medicine, biology, and chemistry. Extensive effort has been directed towards the construction of chiral molecules that contain sp³ hybridized stereogenic centers. In contrast, less effort has been dedicated to molecules that are chiral by...
Resource Type:: Dissertation
Full Text:: ! the! DAEH!system!to!an!acyclic! triphenylether! russuphelol.!The!synthesis!of! the!natural! product

Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

Creator:: Han, Bingnan
Abstract:: This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of eighteen new secondary metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D NMR data, respectively. Preliminary bioassays of the crude...
Resource Type:: Dissertation
Full Text:: ,4° and was the first marine natural product to enter clinical trial as an antitumor agent.41

New bioactive natural products from marine algae and cyanobacteria

Creator:: Sabry, Omar Mohamed
Abstract:: This thesis is an account of investigation on the natural products deriving from various marine algae and has resulted in the discovery of eleven novel bioactive metabolites. Isolation and characterization of these new molecules were carried out using different chromatographic techniques and by analyses of different spectroscopic data, respectively. Using...
Resource Type:: Dissertation
Full Text:: 45% of all current drugs are either a natural product, natural product derivative, or inspired by

Biosynthesis and Rational Design of Novel Pactamycin Analogs

Creator:: Abugrain, Mostafa E.
Abstract:: Pactamycin, a potent antitumor antibiotic produced by the soil bacterium Streptomycespactum, is a structurally unique aminocyclopentitol-containing natural product. Itconsists of a highly functionalized cyclopentitol core unit, two aromatic rings [3-aminoacetophenone (3AAP) and 6-methylsalicylic acid (6MSA)], and a 1,1-dimethylurea moiety. Despite its potent biological activity, the development of thisantibiotic was hampered...
Resource Type:: Dissertation
Full Text:: pactum, is a structurally unique aminocyclopentitol-containing natural product. It consists of a highly

Racemic and Enantioselective Synthesis of Cavicularin

Creator:: Zhao, Peng
Abstract:: This dissertation describes the racemic and enantioselective synthesis cavicularin. Cavicularin is a macrocyclic bisbibenzyls family member natural product. It has been an attractive synthetic target due to its intriguing structure: the macrocyclic core imparts sufficient strain on the system to force one benzene rings to adopt a boat-shaped conformation, out...
Resource Type:: Dissertation
Full Text:: synthesis cavicularin. Cavicularin is a macrocyclic bisbibenzyls family member natural product. It has been

ScholarsArchive@OSU

Bioactive Microbial Natural Products from Unique Indonesian Black Water Ecosystems

Part I: Synthetic studies toward the southern portion of Azaspiracid-1; Part II: Total synthesis of amphidinolide B₁ and the proposed structure of amphidinolide B₂

Ascorbylation- the biological relevance of covalently bound ascorbic acid

Towards the Perfect Marriage Between Theory and Experiments in Drug Discovery and Synthesis : Insights into Structure Determination of Complex Natural Products and Mechanistic Understandings of Lactam Synthesis

Total Synthesis of Goniomitine : Development of Aminal and α-Amino Radicals in the Synthesis of Nitrogen-Rich Natural Products

Conformationally chiral diphenylethers and the enantioselective Ullmann etherification

Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

New bioactive natural products from marine algae and cyanobacteria

Biosynthesis and Rational Design of Novel Pactamycin Analogs

Racemic and Enantioselective Synthesis of Cavicularin

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