Identification of new molecular targets for the treatment of breast cancer is an important clinical goal, especially for triple-negative breast cancer, which is refractory to existing targeted treatments. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor known primarily as the mediator of dioxin toxicity. However, the AhR can...
Coastal and riparian flooding are costly and disruptive natural hazards and already a regular part of life in some areas of the USA. Flooding events caused by sea-level rise and climate change are expected to increase in frequency and severity in the future, creating social, ecological, and economic problems at...
Experts are predicting a major rupture of the Cascadia Subduction Zone (CSZ) sometime within the twenty-first century. When that happens, it will cause an offshore earthquake at a magnitude of 9.0+. After the tremors subside (about 5 min), a powerful tsunami will strike land. Oregon is known for its strong...
Working waterfront industries are reliant upon water access and encompass everything from wild harvest and cultured seafood to towboats, shipping, and marine research. Many of the industries along Oregon’s working waterfronts are inaccessible to the public or hard to see, even though they play critical social and economic roles in...
This chapter synthesizes more than two decades of interdisciplinary scholarship by the coauthors related to fishing families and coastal communities. Amid the contemporary narrative of increasing coastal storms, erosion, and other physical hazards associated with climate and related coastal hazards facing coastal communities, we find myriad ways that Oregon fishing...
Many marine mammal predators, particularly pinnipeds, have increased in abundance in recent decades, generating new challenges for balancing human uses with recovery goals via ecosystem-based management. We used a spatio-temporal bioenergetics model of the Northeast Pacific Ocean to quantify how predation by three species of pinnipeds and killer whales (Orcinus...
Toxoplasma gondii, the most common parasitic infection of human brain and eye, persists across lifetimes, can progressively damage sight, and is currently incurable. New, curative medicines are needed urgently. Herein, we develop novel models to facilitate drug development: EGS strain T. gondii forms cysts in vitro that induce oocysts in...
Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne muscular dystrophy. However, insufficient systemic delivery limits clinical adoption. Previously, we showed that a glucose/fructose mixture augmented AO delivery to muscle in mdx mice. Here, we evaluated if fructose alone could enhance...
Losses of corals worldwide emphasize the need to understand what drives reef decline. Stressors such as overfishing and nutrient pollution may reduce resilience of coral reefs by increasing coral–algal competition and reducing coral recruitment, growth and survivorship. Such effects may themselves develop via several mechanisms, including disruption of coral microbiomes....
Resource managers at the state, federal, and tribal levels make decisions on a weekly to quarterly basis, and fishers operate on a similar timeframe. To determine the potential of a support tool for these efforts, a seasonal forecast system is experimented with here. JISAO’s Seasonal Coastal Ocean Prediction of the...