Index Catalog // ScholarsArchive@OSU

Characterization of the Cellular Respiration and Mitochondrial Metabolism in C2C12 Mouse Myoblasts

Creator:: Sather, Bergen K.
Abstract:: Type-2 diabetes (T2D) has become a pandemic. The main impairment in T2D is skeletal muscle insulin resistance (IR) and is often associated with obesity. Despite decades of study, the mechanisms of IR have not been fully resolved. Evidence has implicated mitochondrial dysfunction as a potential cause and/or consequence of IR....
Resource Type:: Honors College Thesis
Full Text:: :_____________________________________________________ Sean Newsom Type-2 diabetes (T2D) has become a pandemic. The main impairment in T2D is

Regulation of muscle fat oxidation and storage by ACSL enzymes and effects of acute exercise training in humans

Creator:: Boechler, Victoria
Abstract:: The increase in obesity rates in both children and adults in the United States may be a result of impaired or dysregulation of fat metabolism. Long chain acyl-CoA synthetases (ACSLs) may be key regulators of skeletal muscle cell fat metabolism, including fat oxidation and storage. The purpose of the study...
Resource Type:: Honors College Thesis
Full Text:: Newsom The increase in obesity rates in both children and adults in the United States may be a

Regulation of Skeletal Muscle Insulin Action and Fatty Acid Trafficking with Obesity and Exercise

Creator:: Stierwalt, Harrison D.
Abstract:: Altered skeletal muscle fat metabolism is linked to changes in skeletal muscle insulin sensitivity. Whereby the accumulation of bioactive signaling lipids (i.e., diacylglycerols and ceramides) within skeletal muscle are negatively associated with insulin sensitivity and the exercise-induced changes to fatty acid trafficking are related to improved skeletal muscle insulin action....
Resource Type:: Dissertation
Full Text:: Abstract approved: ______________________________________________________ Sean A. Newsom

Regulation of skeletal muscle mitochondria in response to obesity and exercise in mice and humans

Creator:: Batterson, Philip M.
Abstract:: Skeletal muscle mitochondria are highly plastic organelles, integral to whole-body health. High-fat diet (HFD) and exercise remodel the skeletal muscle mitochondria. Whereby, altered skeletal muscle mitochondrial function is linked to decreased skeletal muscle insulin sensitivity which can be reversed by exercise. However, the mechanisms that contribute to skeletal muscle remodeling...
Resource Type:: Dissertation
Full Text:: Sean A. Newsom Skeletal muscle mitochondria are highly plastic organelles

Regulation of Skeletal Muscle Mitophagy in Response to High-fat Feeding and Exercise Training

Creator:: Ehrlicher, Sarah E.
Abstract:: Understanding the mechanisms regulating mitochondrial respiratory function and adaptations to metabolic challenges, such as exercise and high dietary fat, is necessary to promote skeletal muscle health and attenuate metabolic disease. Autophagy is a constitutively active degradation pathway that promotes mitochondrial turnover and is suppressed by insulin and activated by exercise....
Resource Type:: Dissertation
Full Text:: . Robinson and Sean A. Newsom Understanding the mechanisms regulating mitochondrial respiratory function

Characterization of Mitochondrial Metabolism in L6 Rat Myoblasts

Creator:: Burney, Emily R.
Abstract:: The prevalence of obesity is increasing worldwide, causing a subsequent increase in insulin resistance (IR), metabolic disorders, and cardiovascular diseases. Although these conditions significantly impact both the individual and society, their etiologies have not been discovered, inhibiting potential prevention and treatment. Alterations to mitochondrial metabolism are implicated in the development...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Sean Newsom, Committee Member, representing Biological and Population Health Sciences

Strength Training for Triathletes : Blending Anecdotal and Empirical Evidence to Improve Triathlon Performance

Creator:: Le, Kevin J.
Abstract:: Triathlon is an endurance sport consisting of back-to-back swimming, cycling, and running. There are four popular distances: sprint (.75k m swim, 20km bike, 5km run), Olympic (1.5km swim, 40km bike, 10km run), half-ironman (1.9km swim, 90km bike, 21.1km run), and ironman (3.8km swim, 180km bike, 42.2km run). Even at the...
Resource Type:: Honors College Thesis
Full Text:: education at OSU. Thank you to Sean Newsom for also being a great professor and stepping in last second

Through the Eyes of Five: Combating Pandemic Amnesia Through the Collection and Preservation of COVID-19 Stories

Creator:: Celaya, Alanna
Abstract:: The 1918-1919 influenza pandemic led to a phenomenon termed as pandemic amnesia. It is apparent that the COVID-19 pandemic has revealed a disturbingly similar pattern. My thesis investigated the prevalence and perils of pandemic amnesia in the context of COVID-19. I explored this issue through a review of scholarly literature...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Sean Newsom, Committee Member, representing School of Exercise, Sport, and Health Sciences

The Effect of Riluzole on P2X7 and EAAT2 Expression by Inducible Neural Progenitor Cell (iNPC)-derived Astrocytes

Creator:: Sy, Kevin
Abstract:: Although it is the first drug approved for usage to treat amyotrophic lateral sclerosis (ALS), riluzole’s mechanism of action is unknown and its therapeutic quality is hampered by its relatively short window of effectiveness. P2X7 is a purine receptor found in astrocytes and other cells, which increases calcium concentrations within...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Sean Newsom, Committee Member, representing Biological and Population Health Sciences

Short-Term Lipid Overload in Skeletal Muscle Induces Mild Mitochondrial Membrane Depolarization as a Stimulus for Autophagy Activation

Creator:: Brinck, Isabel M.
Abstract:: Type 2 Diabetes Mellitus is a chronic metabolic condition that impairs insulin stimulated glucose absorption in skeletal muscle, a characteristic phenomenon denoted as insulin resistance. Lipid overload of the mitochondria is linked to the development of insulin resistance and the progression of Type 2 Diabetes. As lipids accumulate there is...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Sean Newsom, Committee Member, representing the School of Biological and Population Health

ScholarsArchive@OSU

Characterization of the Cellular Respiration and Mitochondrial Metabolism in C2C12 Mouse Myoblasts

Regulation of muscle fat oxidation and storage by ACSL enzymes and effects of acute exercise training in humans

Regulation of Skeletal Muscle Insulin Action and Fatty Acid Trafficking with Obesity and Exercise

Regulation of skeletal muscle mitochondria in response to obesity and exercise in mice and humans

Regulation of Skeletal Muscle Mitophagy in Response to High-fat Feeding and Exercise Training

Characterization of Mitochondrial Metabolism in L6 Rat Myoblasts

Strength Training for Triathletes : Blending Anecdotal and Empirical Evidence to Improve Triathlon Performance

Through the Eyes of Five: Combating Pandemic Amnesia Through the Collection and Preservation of COVID-19 Stories

The Effect of Riluzole on P2X7 and EAAT2 Expression by Inducible Neural Progenitor Cell (iNPC)-derived Astrocytes

Short-Term Lipid Overload in Skeletal Muscle Induces Mild Mitochondrial Membrane Depolarization as a Stimulus for Autophagy Activation

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