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  • Origins and evolution of plant microRNA genes

    Creator:
    Fahlgren, Noah
    Abstract:
    Eukaryotic small RNA (~20-30 nucleotides) are diverse regulatory molecules that repress gene expression at the transcriptional and post-transcriptional levels, defend hosts against invading viruses and defend genomes against selfish DNA elements. Small RNA populations are studied by high-throughput sequencing of the total small RNA fraction isolated from cells, however, the...
    Resource Type:
    Dissertation
    Full Text:
    small RNA that are processed from longer transcripts. MIRNA genes encode non-coding RNAs that are

  • Rapid evolution of post-transcriptionally regulated RESTORER OF FERTILITY-LIKE genes in the genus Arabidopsis

    Creator:
    Jogdeo, Sanjuro
    Abstract:
    The Pentatricopeptide Repeat (PPR) gene family produces RNA-binding proteins that target organellar transcripts. The PPR family is expanded in land plants, with nearly 450 genes identified in Arabidopsis thaliana. In plants with a Cytoplasmic Male Sterility (CMS) phenotype, members of the PPR family can act as a RESTORER OF FERTILITY...
    Resource Type:
    Masters Thesis
    Full Text:
    RNAs (siRNA). For instance, the non-protein coding trans-acting siRNA-generating (TAS) genes are

  • Sulforaphane Regulation of LncRNA in a Transplacental Nrf2 Knockout Mouse Model Exposed to Dibenzo[def,p]chrysene

    Creator:
    Patel, Karan A.
    Abstract:
    Dibenzo[def,p]chrysene (DBC) is a highly potent, but less prevalent, environmental carcinogen belonging to a class of compounds known as Polycyclic Aromatic Hydrocarbons (PAHs). They are highly ubiquitous and arise as a byproduct of natural and anthropogenic combustion processes. Previous studies have documented carcinogenic effects upon in utero exposure of PAHs....
    Resource Type:
    Honors College Thesis
    Full Text:
    of various long non-coding RNA (lncRNA >200bp) utilizing a Nrf2 Knockout Mouse Model. LncRNA have

  • Endogenous and antiviral RNA silencing pathways in Arabidopsis

    Creator:
    Chapman, Elisabeth J.
    Abstract:
    RNA silencing pathways are required for a wide variety of processes in most eucaryotes. In plants, small-interfering RNA (siRNA) arising from transposons and other repetitive sequences is associated with heterochromatin formation and maintenance. MicroRNAs and trans-acting siRNAs encoded at discrete loci function as negative regulators of gene expression by triggering...
    Resource Type:
    Dissertation
    Full Text:
    of the ARGONAUTE and PIWI families). Therefore, evolution of the RNA silencing mechanism as a