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  • Regulation of Skeletal Muscle Mitophagy in Response to High-fat Feeding and Exercise Training

    Creator:
    Ehrlicher, Sarah E.
    Abstract:
    Understanding the mechanisms regulating mitochondrial respiratory function and adaptations to metabolic challenges, such as exercise and high dietary fat, is necessary to promote skeletal muscle health and attenuate metabolic disease. Autophagy is a constitutively active degradation pathway that promotes mitochondrial turnover and is suppressed by insulin and activated by exercise....
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    Dissertation
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    Drs. Donald Jump, Viviana Perez and Adam Branscum, thank you for serving on my committee and for

  • Structural Insights into Novel Sugar Phosphate Cyclases and Flavoenzymes

    Creator:
    Kean, Kelsey M.
    Abstract:
    The function of a protein is defined by its three-dimensional structure, and in understanding the three-dimensional structure of a protein, we gain an understanding of its function and mechanism. Protein structures, especially at high resolution, can provide detailed insights into many elements of enzyme function and catalysis – identifying residues...
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    Dissertation
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    clear documentation which has made my life much easier). I also thank Viviana Perez and Shelley Su, my

  • Functional and Structural Analyses of Three Distinct proteins by Biochemical and Biophysical Techniques

    Creator:
    Codding, Sara Jone
    Abstract:
    The focus of this dissertation was to understand protein function and structure ona molecular level. To do this successfully, a variety of biochemical and biophysicaltechniques were employed. A wide variety of techniques were applied to study theproteins of interest in this dissertation to probe protein-protein interactions, proteinfunction, protein structure, and...
    Resource Type:
    Dissertation

  • Oxidative stress in amyotrophic lateral sclerosis : the role of cellular senescence and glutathione

    Creator:
    Beilby, Pamela R.
    Abstract:
    Amyotrophic lateral sclerosis (ALS) is a devastating neurological disorder characterized by neuromuscular junction decay, motor neuron death, progressive paralysis, and eventually death of the individual, usually by respiratory failure. Oxidative stress is a prominent hallmark of the disease and is often accompanied and exacerbated by mitochondrial dysfunction and neuroinflammation. This...
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    Dissertation
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    . Thank you all for laughter and listening. Thank you especially to my committee members, Viviana Pérez

  • Initial in vitro and in vivo Characterization of the Membrane Trafficking Protein Fer1L6

    Creator:
    Wolk, Chelsea
    Abstract:
    A fundamental difference between prokaryotic and eukaryotic cells is the presence of membrane bound organelles in eukaryotes. The dynamics of membrane trafficking within the cell are responsible for everything from intercellular communication and cell homeostasis, to mitosis, cell migration, and differentiation. These processes require exocytosis and compensatory endocytosis, often working...
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    Dissertation
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     their input and guidance.  Thank you to Dr. Viviana  Perez, Dr. Barbara Taylor, Dr. Julie Greenwood, Dr

  • Evolutionary Genomic Responses to Mitochondrial Dysfunction in Caenorhabditis elegans

    Creator:
    Wernick, Riana I.
    Abstract:
    Understanding the impact of mitochondrial dysfunction on genome evolution has the potential not only to provide new insights on the basic evolutionary processes influencing mitochondrial and nuclear genomes, but may also reveal novel avenues for evolutionary adaptive recovery from harmful mutations. Aberrant mitochondrial activity is fundamental to the pathology of...
    Resource Type:
    Dissertation
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    achieve my goals. I would also like to thank my committee members Drs. Suzanne Estes, Viviana Perez

  • Investigating connections between the circadian system and aging in Drosophila melanogaster

    Creator:
    Long, Dani M.
    Abstract:
    Circadian clocks coordinate molecular, cellular, physiological, and behavioral processes with the 24-hour solar day. While clock functions are well understood in young animals, it is not clear how aging or neurodegenerative disease affects the various levels of the circadian system. A common symptom of many neurodegenerative diseases including Alzheimer’s disease...
    Resource Type:
    Dissertation
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    members: Dr. Barb Taylor, Dr. Patrick Chappell, Dr. Viviana Perez, and Dr. Kathy Magnusson for their

  • Age-related decrease in resilience against acute redox cycling agents: Critical role of declining GSH-dependent detoxification capacity

    Creator:
    Thomas, Nicholas O.
    Abstract:
    Over the past century, life expectancy in the United States has dramatically increased leading to an increasingly aging population with people reaching, and spending more years in ‘old age’. While this unprecedented shift in population demographics represents great strides for humanity, it is not without cost. One consequence of longer...
    Resource Type:
    Dissertation
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    committee members, Viviana Perez, Sarina Saturn, Dave Williams, Nancy Kerkvliet, and Tony Wilcox