Index Catalog // ScholarsArchive@OSU

1) Preparation of Acetaminophen Capsules Containing Beads Prepared by Hot-melt Direct Blend Coating Method 2) Pharmacokinetic Modeling and Monte Carlo Simulations in The Context of Additional Criteria for Bioequivalence Assessments 3) Pharmacokinetic Prediction of Levofloxacin Accumulation in Tissue and its Association to Tendinopathy

Creator:: Pham, Loan
Abstract:: The thrust of this thesis is to study oral solid dosage formulation using hot melt coating method and to use pharmacokinetic modeling and simulation (PK M&S) as a tool that can help to predict pharmacokinetics of a drug in human and the probability of passing various bioequivalence criteria of the...
Resource Type:: Dissertation
Full Text:: Assessments 3) Pharmacokinetic Prediction of Levofloxacin Accumulation in Tissue and its Association to

New product formulation and multiple dose pharmacokinetics of acetaminophen

Creator:: Sahajwalla, Chandrahas G.
Abstract:: Four different treatments of acetaminophen were administered to eight healthy volunteers in multiple doses (five doses). Saliva acetaminophen concentration-time profiles were determined. Non-compartmental pharmacokinetic parameters for the first and last dose were calculated and compared to determine whether acetaminophen exhibited linear or dose dependent pharmacokinetics. Dose corrected area under the...
Resource Type:: Dissertation
Full Text:: . Bioavailability studies of some suspension formulations were conducted in two subjects and compared to an

Pharmacokinetic analysis of antimicrobials and an anthelmintic agent in alpacas and llamas with theoretical applications

Creator:: Wattananat, Triporn
Abstract:: The pharmacokinetics of two antimicrobials were investigated in alpacas. Six healthy alpacas were each administered a single dose of 10 mg/kg of oxytetracycline by IV injection and IM injection. In addition, a single dose of 20 mg/kg of florfenicol by IV administration was given to alpacas in a separate study....
Resource Type:: Dissertation
Full Text:: given to alpacas in a separate study. The pharmacokinetic parameters of oxytetracychne and florfenicol

The Response to Sulforaphane in Metastatic Prostate Cancer Cells

Creator:: Watson, Gregory
Abstract:: Sulforaphane is an isothiocyanate derived from cruciferous vegetables and has been under investigation as a cancer chemopreventive agent for over two decades. The compound is well tolerated and has been shown to slow cancer progression in several different pre-clinical models of carcinogenesis, such as of the lung, breast and colon....
Resource Type:: Dissertation
Full Text:: increased HDAC6 and p62 association…. 92 4.7 Tubacin leads to the appearance of LC3 puncta in PC3 cells

The study of pharmacokinetics in a clinical environment

Creator:: Tse, Sunny
Abstract:: This dissertation presents a research series demonstrating the use of pharmacokinetic modeling and simulations as tools to assess drug concentration and disposition in patient populations. For drugs requiring therapeutic drug monitoring, these tools are necessary to ensure patients are receiving a safe and effective dose of medication to address their...
Resource Type:: Dissertation
Full Text:: demonstrating the use of pharmacokinetic modeling and simulations as tools to assess drug concentration and

Characterization of the Mechanistic Basis for the Cytotoxic Activity of Select Macrocyclic Natural Products against Glioblastoma Cells

Creator:: Serrill, Jeffrey D.
Abstract:: Natural products from both terrestrial and marine sources represent a significant source of novel drug leads, and have previously been developed into clinically-approved agents for the treatment of various human diseases. This work represents the biological characterization of the mechanistic basis for activity of several natural product structures in models...
Resource Type:: Dissertation
Full Text:: Characterization of HUVEC morphology and viability in response to coibamide A and apratoxin A

Hydrocortisone permeation study using a synthetic membrane, mouse skin and an epiderm cultured skin, Preparation of orally disintegrating tablets of melatonin and acetaminophen, Pharmacokinetics of terbinafine in penguins

Creator:: Le, Hang Thi
Abstract:: The first project of this thesis is an in vitro study. This study was performed with 8 hydrocortisone topical products on the market for the purpose of comparing one Tec Lab product, a Corticool gel, to the other seven common products on the market. The permeation of these products was...
Resource Type:: Dissertation
Full Text:: thickness of the stratum coneum varies according to its position on the body, palms and soles being the

Development of a physiologically based pharmacokinetic model for assessment of human exposure to bisphenol A

Creator:: Yang, Xiaoxia, Doerge, Daniel R, Teeguarden, Justin G., and Fisher, Jeffrey W.
Abstract:: A previously developed physiologically based pharmacokinetic (PBPK) model for bisphenol A (BPA) in adult rhesus monkeys was modified to characterize the pharmacokinetics of BPA and its phase II conjugates in adult humans following oral ingestion. Coupled with in vitro studies on BPA metabolism in the liver and the small intestine,...
Resource Type:: Article
Full Text:: bisphenol A (BPA) in adult rhesus monkeys was modified to characterize the pharmacokinetics of BPA and its

24-hour human urine and serum profiles of bisphenol A: Evidence against sublingual absorption following ingestion in soup

Creator:: Teeguarden, Justin G., Twaddle, Nathan C., Churchwell, Mona I., Yang, Xiaoxia, Fisher, Jeffrey W., Seryak, Liesel M., and Doerge, Daniel R.
Abstract:: Extensive first-pass metabolism of ingested bisphenol A (BPA) in the gastro-intestinal tract and liver restricts blood concentrations of bioactive BPA to < 1% of total BPA in humans and non-human primates. Absorption of ingested BPA through non-metabolizing tissues of the oral cavity, recently demonstrated in dogs, could lead to the...
Resource Type:: Article
Full Text:: to b1% of total BPA in humans and non-human primates. Absorption of ingested BPA through non

From pesticide degradation products to legacy toxicants and emerging contaminants : novel analytical methods, approaches, and modeling

Creator:: Forsberg, Norman D.
Abstract:: Environmental toxicologists and public health officials are responsible for assisting in the identification, management, and mitigation of public health hazards. As a result, there is a continued need for robust analytical tools that can aid in the rapid quantification and characterization of chemical exposure. In the first research phase, we...
Resource Type:: Dissertation
Full Text:: biomonitoring studies and specific examples of DAPs found in urine following exposure to the OPs phosalone (A

ScholarsArchive@OSU

New product formulation and multiple dose pharmacokinetics of acetaminophen

Pharmacokinetic analysis of antimicrobials and an anthelmintic agent in alpacas and llamas with theoretical applications

The Response to Sulforaphane in Metastatic Prostate Cancer Cells

The study of pharmacokinetics in a clinical environment

Characterization of the Mechanistic Basis for the Cytotoxic Activity of Select Macrocyclic Natural Products against Glioblastoma Cells

Hydrocortisone permeation study using a synthetic membrane, mouse skin and an epiderm cultured skin, Preparation of orally disintegrating tablets of melatonin and acetaminophen, Pharmacokinetics of terbinafine in penguins

Development of a physiologically based pharmacokinetic model for assessment of human exposure to bisphenol A

24-hour human urine and serum profiles of bisphenol A: Evidence against sublingual absorption following ingestion in soup

From pesticide degradation products to legacy toxicants and emerging contaminants : novel analytical methods, approaches, and modeling

Limit your search

Academic Affiliation

Advisor

Commencement Year

Committee Member

Creator

Contributor

Date

Decade

Degree Field

Degree Level

Degree Name

File Format

Language

License

Location

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Subject

Search Constraints

Search Results

Limit your search