Index Catalog // ScholarsArchive@OSU

Synthetic studies toward a total synthesis of paeoniflorigenin

Creator:: Hong, Zhenqiu
Abstract:: A new approach towards a total synthesis of paeoniflorigenin is discussed. The approach involves the application of regio- and stereoselective [2+2] photocycloaddition for the preparation of a key intermediate, cyclobutanone 86, and model studies on diiodosamarium (Sm12) mediated pinacol coupling of a diketone. Intermolecular [2+2] photocycloaddition of a,13unsaturated lactam 33...
Resource Type:: Masters Thesis
Full Text:: stereochemistry of intermolecular [2+2] photoaddition product 35 23 2. NOE studies on cyclobutanol 85 46

Himeradine A : synthetic efforts towards himeradine A and related natural products, a Michael reaction focused approach

Creator:: Collett, Nathan D.
Abstract:: Lycopodium alkaloids have generated enormous amounts of interest from the scientific community, both as synthetic targets and for their medicinal properties. Herein is described work towards a unifying approach to large segments of the Lycopodium family. An organocatalyzed intramolecular heteroatom Michael reaction method, for the construction of piperidine and piperizine...
Resource Type:: Dissertation
Full Text:: Product Synthesis……………………………..25 2.5: Conclusion…………………………………………………………27 Chapter 3: Studies Towards

Synthetic studies on marine natural products : I. Stereoselective synthesis of E,Z-1,3-Dienes by tandem nucleophilic addition to a dienylphosphonium salt followed by Wittig reaction. II. Synthesis of cyclopropyl oxylipins by a cation mediated carbocyclization

Creator:: Jensen, Mark S.
Resource Type:: Dissertation
Full Text:: example, enyne 1, the product of coupling an E vinyl iodide with an acetylene, underwent hydroboration

Synthetic studies on natural products : Part I. The total synthesis of ±-euonyminol and ±-3,4-dideoxymaytol : Part II. The absolute configuration and enantioselective synthesis of curacin A

Creator:: Kim, Tae-Seong
Resource Type:: Dissertation
Full Text:: , Ewha Kang and Sul-Am Kim in appreciation of their love. Synthetic Studies on Natural Product

Studies toward the synthesis of coibamide A and analogues

Creator:: Li, Dong
Abstract:: Coibamide A is a highly methylated cyclic depsipeptide isolated from Panamanian marine filamentous cyanobacteria as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. This structurally unique agent exhibits potent cancer cell toxicity with an unprecedented selectivity profile in the National Cancer Institute (NCI) 60 cell line...
Resource Type:: Dissertation
Full Text:: natural product coibamide A according to HPLC, 1H NMR and activity test. By Marfey’s analysis, we found

Racemic and Enantioselective Synthesis of Cavicularin

Creator:: Zhao, Peng
Abstract:: This dissertation describes the racemic and enantioselective synthesis cavicularin. Cavicularin is a macrocyclic bisbibenzyls family member natural product. It has been an attractive synthetic target due to its intriguing structure: the macrocyclic core imparts sufficient strain on the system to force one benzene rings to adopt a boat-shaped conformation, out...
Resource Type:: Dissertation
Full Text:: synthesis cavicularin. Cavicularin is a macrocyclic bisbibenzyls family member natural product. It has been

The development of aminal radicals for the synthesis of nitrogen-rich natural products

Creator:: Schiedler, David A.
Abstract:: Organic compounds which contain one or more nitrogen atoms are especially important as they are disproportionately represented among biologically active molecules. As a result, significant effort has been focused on the development of methods for the synthesis of nitrogenous molecules. We identified the aminal as an under-explored functional group. Despite...
Resource Type:: Dissertation
Full Text:: product of bond formation at the aminal carbon. Chemical yields of the radical translocation reactions

Synthesis of marine natural products. part I, Cryptophycins-1, -3, -4, -24, and -29, part II, Polycavernoside A

Creator:: Robarge, Lonnie A.
Resource Type:: Dissertation
Full Text:: macrolactamization (Scheme 9). The Boc protecting group and tert-butyl ester of each coupled product were cleaved in

Towards the Perfect Marriage Between Theory and Experiments in Drug Discovery and Synthesis : Insights into Structure Determination of Complex Natural Products and Mechanistic Understandings of Lactam Synthesis

Creator:: Snyder, Kevin M.
Abstract:: In this report, three studies are presented that aid in the development of drug discovery and their synthesis. In each, the importance of the marriage between computations and experiments is highlighted. Continued efforts in this vein are essential for future efforts towards improving human health. The first case study investigated...
Resource Type:: Masters Thesis
Full Text:: ] residues are inverted from L to D, was consistent with the spectra of the authentic natural product. In

Total Synthesis of Goniomitine : Development of Aminal and α-Amino Radicals in the Synthesis of Nitrogen-Rich Natural Products

Creator:: Vellucci, Jessica K.
Abstract:: Aminal radical intermediates were generated by the method of radical translocation and reacted in C-C bond forming reactions with electronically deficient alkenes (Schiedler et al. Org. Lett. 2012, 14, 6092). Aminal radical intermediates can participate in inter- and intra-molecular reactions using both Bu3SnH and (TMS)₃SiH as hydride donors. Carbon–carbon bonds...
Resource Type:: Dissertation
Full Text:: ethyl-substituted lactam providing the corresponding N-aryl coupling product in 96% yield. Subsequent

ScholarsArchive@OSU

Synthetic studies toward a total synthesis of paeoniflorigenin

Himeradine A : synthetic efforts towards himeradine A and related natural products, a Michael reaction focused approach

Synthetic studies on marine natural products : I. Stereoselective synthesis of E,Z-1,3-Dienes by tandem nucleophilic addition to a dienylphosphonium salt followed by Wittig reaction. II. Synthesis of cyclopropyl oxylipins by a cation mediated carbocyclization

Synthetic studies on natural products : Part I. The total synthesis of ±-euonyminol and ±-3,4-dideoxymaytol : Part II. The absolute configuration and enantioselective synthesis of curacin A

Studies toward the synthesis of coibamide A and analogues

Racemic and Enantioselective Synthesis of Cavicularin

The development of aminal radicals for the synthesis of nitrogen-rich natural products

Synthesis of marine natural products. part I, Cryptophycins-1, -3, -4, -24, and -29, part II, Polycavernoside A

Towards the Perfect Marriage Between Theory and Experiments in Drug Discovery and Synthesis : Insights into Structure Determination of Complex Natural Products and Mechanistic Understandings of Lactam Synthesis

Total Synthesis of Goniomitine : Development of Aminal and α-Amino Radicals in the Synthesis of Nitrogen-Rich Natural Products

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