Index Catalog // ScholarsArchive@OSU

Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

Creator:: Madeen, Erin
Abstract:: The objective of this work is to add to the body of translational data between high dose animal model research and the environmentally relevant human metabolism of the persistent pollutant dibenzo[def,p]chrysene (DBC). We furthered the knowledge of gene/exposure interactions by determining the carcinogenesis risk based on Cyp1b1 genotype following in...
Resource Type:: Dissertation
Full Text:: High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and

Human in vivo Pharmacokinetics of [¹⁴C]Dibenzo[def,p]chrysene by Accelerator Mass Spectrometry Following Oral Micro-Dosing

Creator:: Madeen, Erin, Corley, Richard A., Crowell, Susan, Turteltaub, Kenneth, Ognibene, Ted, Malfatti, Mike, McQuistan, Tammie J., Garrard, Mary, Sudakin, Dan, and Williams, David E.
Abstract:: Dibenzo(def,p)chrysene (DBC), (also known as dibenzo[a,l]pyrene), is a high molecular weight polycyclic aromatic hydrocarbon (PAH) found in the environment, including food, produced by the incomplete combustion of hydrocarbons. DBC, classified by IARC as a 2A probable human carcinogen, has a relative potency factor (RPF) in animal cancer models 30-fold higher...
Resource Type:: Article

Creating Isogenic Cell Cultures for Functional Studies of DNA Mismatch-Repair

Creator:: Sarver, Kimberly
Abstract:: Colorectal cancer (CRC), the third leading cause of cancer death in the USA, depends on early detection for patient survival. Early detection is improved with the identification of high risk individuals. Risk of CRC development is a complex interaction between an individual’s genetics and environmental exposures. Polycyclic Aromatic Hydrocarbons (PAHs)...
Resource Type:: Undergraduate Thesis and Presentation

Zero Kinetic Energy Photoelectron Spectroscopy of Polycyclic Aromatic Hydrocarbons

Creator:: Harthcock, Colin
Abstract:: In this dissertation, I describe spectroscopic studies of jet-cooled polycyclic aromatic hydrocarbons (PAH) and one nitrogen substituted PAH (PANH) using pulsed field zero kinetic energy (ZEKE) photoelectron spectroscopy and resonantly enhanced multiphoton ionization (REMPI) spectroscopy. Recently, there has been a demand for far-infrared (FIR) spectral information of astrophysically relevant molecules...
Resource Type:: Dissertation
Full Text:: Spectra for Polycyclic Aromatic Hydrocarbon Neutrals, Cations, and Anions. J. Phys. Chem. 1996, 100, 2819

Toxicity and Mutagenicity of Polycyclic Aromatic Hydrocarbons in Contaminated Soils using Mammalian In Vitro Assay

Creator:: Luker, George W.
Abstract:: There exists a growing need to establish a better in vitro model for evaluating PAH toxicity and carcinogenicity and to improve assessments of risk to human health, especially to the complex mixtures that exist in the environment. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants due to the incomplete combustion...
Resource Type:: Undergraduate Thesis
Full Text:: Toxicity and Mutagenicity of Polycyclic Aromatic

Identification, Quantification, and Risk Assessment of Polycyclic Aromatic Hydrocarbons and their Derivatives in Soil after Steam Enhanced Extraction

Creator:: Santiago Delgado, Lisandra
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are environmental contaminants produced mainly from the incomplete combustion and pyrolysis of organic matter. PAHs are among the major contaminants at over 800 Superfund sites, nationwide. Thermal remediation is used as a method to remediate soils contaminated with PAHs through the use of heat to mobilize...
Resource Type:: Masters Thesis
Full Text:: December 6, 2017. Title: Identification, Quantification, and Risk Assessment of Polycyclic Aromatic

Defining PAH and Oxygen-substituted PAH-dependent Developmental and Adult Toxicity in Zebrafish

Creator:: Knecht, Andrea L.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) and oxygen-substituted PAHs (OPAHs) are environmental contaminants present in urban air, dust, soil and water resulting from incomplete combustion of organic materials or fossil fuels; found in crude oil and coal; and formed through photoxidation or biotransformation of microbial. It is widely recognized that PAHs pose...
Resource Type:: Dissertation
Full Text:: . Gale, S. L., E. M. Noth, et al. (2012). "Polycyclic aromatic hydrocarbon exposure and wheeze in a

Developmental toxicity of polycyclic aromatic hydrocarbons : defining mechanisms with systems-based transcriptional profiling

Creator:: Goodale, Britton C.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment as components of fossil fuels and by-products of combustion. Defining toxicity mechanisms for this large family of multi-ring structures and substituted derivatives is a substantial challenge. Several PAHs, such as benzo(a)pyrene (BaP), are mutagenic, toxic to wildlife, and classified as probable...
Resource Type:: Dissertation
Full Text:: ...................................................................................................... 23 Figure 1-3 Polycyclic aromatic hydrocarbon structures

Assessing mechanisms of immunotoxicity for polycyclic aromatic hydrocarbons in rainbow trout (Oncorhynchus mykiss)

Creator:: Bravo, Claudia F.
Abstract:: During the past 30 years, numerous studies have focused on the toxicities of polycyclic aromatic hydrocarbons (PAH). Laboratory and field studies have helped elucidate the detrimental effects of these chemicals on growth, reproduction and immune response. Polycyclic aromatic hydrocarbons are in the priority list of chemicals to be studied by...
Resource Type:: Dissertation
Full Text:: of Immunotoxicity for Polycyclic Aromatic Hydrocarbons in Rainbow Trout (Oncorhynchus inykiss

Human exposure to polycyclic aromatic hydrocarbons : global cancer risk and metabolism

Creator:: Motorykin, Oleksii
Abstract:: In recent decades, there has been increased attention on human exposure to, and subsequently toxicity of, Polycyclic Aromatic Hydrocarbons (PAHs). PAHs are widespread organic pollutants and some have been shown to be toxic, carcinogenic and mutagenic. This research was focused on understanding the link between global PAH emissions and lung...
Resource Type:: Dissertation
Full Text:: ................................................................................................... 7 2. ASSOCIATION OF CARCINOGENIC POLYCYCLIC AROMATIC HYDROCARBON EMISSIONS AND SMOKING WITH LUNG

ScholarsArchive@OSU

Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

Human in vivo Pharmacokinetics of [¹⁴C]Dibenzo[def,p]chrysene by Accelerator Mass Spectrometry Following Oral Micro-Dosing

Creating Isogenic Cell Cultures for Functional Studies of DNA Mismatch-Repair

Zero Kinetic Energy Photoelectron Spectroscopy of Polycyclic Aromatic Hydrocarbons

Toxicity and Mutagenicity of Polycyclic Aromatic Hydrocarbons in Contaminated Soils using Mammalian In Vitro Assay

Identification, Quantification, and Risk Assessment of Polycyclic Aromatic Hydrocarbons and their Derivatives in Soil after Steam Enhanced Extraction

Defining PAH and Oxygen-substituted PAH-dependent Developmental and Adult Toxicity in Zebrafish

Developmental toxicity of polycyclic aromatic hydrocarbons : defining mechanisms with systems-based transcriptional profiling

Assessing mechanisms of immunotoxicity for polycyclic aromatic hydrocarbons in rainbow trout (Oncorhynchus mykiss)

Human exposure to polycyclic aromatic hydrocarbons : global cancer risk and metabolism

Limit your search

Academic Affiliation

Advisor

Commencement Year

Committee Member

Creator

Date

Decade

Degree Field

Degree Level

Degree Name

File Format

Language

License

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Subject

Search Constraints

Search Results

Limit your search