Dendrimers are well-defined, polymeric nanomaterials currently being investigated for their biomedical applications. Initially, higher generation (size) dendrimers were of interest because of their drug carrying capacity. However, increased generation was associated with increased toxicity. The objective of the present study was to investigate the role of surface charge and generation...
A Cr₂0₃, and cellulose fibre mixture was used with cattle, in
three grazing and two semi-restricted experiments, to study the mode
of its excretion, the possibility of using it in a once-daily dosing and
grab-sample regime to estimate fecal output and in a field experiment
to test a hypothesis involving...
The ever-increasing global population presents looming problems for the field of agriculture. Global food demand will, at some point, increase to the point where there is not enough crop-ready land to keep up. This creates an additional incentive, other than economics, for growers to increase their yield-per-acre and make sure...
The paper describes a Thermally-Enhanced Edge Registration (TEER) technique for precision aligning large numbers of laminae in diffusion bonding processes. This technique is particularly relevant for the formation of micro heat exchangers and microreactors requiring highly paralleled microchannel arrays but is also being used to register other laminated devices with...
A system to reversibly extract Pb²⁺ ions from aqueous solutions using spiropyran functionalized nanofibers was proposed. Spiropyrans are photochromic compounds which undergo a conformational change that alters their physical properties and makes Pb²⁺ binding possible upon irradiation with UV light (365 nm). Irradiation with green light (525 nm) reverses this...
Dendrimers are well-defined, polymeric nanomaterials currently being investigated for biomedical applications such as medical imaging, gene therapy, and tissue targeted therapy. Initially, higher generation (size) dendrimers were of interest because of their drug carrying capacity. However, increased generation was associated with increased toxicity. The majority of studies exploring dendrimer toxicity...
Inherent nanomaterial characteristics, composition,
surface chemistry, and primary particle size,
are known to impact particle stability, uptake, and
toxicity. Nanocomposites challenge our ability to predict
nanoparticle reactivity in biological systems if they
are composed of materials with contrasting relative
toxicities. We hypothesized that toxicity would be
dominated by the nanoparticle...
Full Text:
toxicity of engineered silver
nanoparticles
Josephine A. Bonventre • Joseph B. Pryor •
Bryan J. Harper
Inherent nanomaterial characteristics, composition,
surface chemistry, and primary particle size,
are known to impact particle stability, uptake, and
toxicity. Nanocomposites challenge our ability to predict
nanoparticle reactivity in biological systems if they
are composed of materials with contrasting relative
toxicities. We hypothesized that toxicity would be
dominated by the nanoparticle...
Inherent nanomaterial characteristics, composition, surface chemistry, and primary particle size, are known to impact particle stability, uptake, and toxicity. Nanocomposites challenge our ability to predict nanoparticle reactivity in biological systems if they are composed of materials with contrasting relative toxicities. We hypothesized that toxicity would be dominated by the nanoparticle...
A more quantitative understanding of peptide loading and release from polyethylene oxide (PEO) brush layers will provide direction for development of new strategies for drug storage and delivery. The antimicrobial peptide nisin shows potent activity against Gram-positive bacteria including the most prevalent implant-associated pathogens, its mechanism of action minimizes the...
