The plant Senecio jacobaea (tansy ragwort) produces several macrocyclic pyrrolizidine alkaloids which cause irreversible liver cirrhosis. All of the pyrrolizidine alkaloids in Senecio jacobaea are macrocyclic diesters of the necine base retronecine, with the two most predominant being seneciphylline and jacobine. Unlike horses and cattle, sheep and goats are generally...
There have been many studies that describe the protective degradation or metabolism of potentially harmful plant toxins, such as, mimosine from Leucaena leuconcephala, pyrrolizidine alkaloids from tansy ragwort (Senecio jacobaea), oxalate and some mycotoxins by rumen microbes. There are many cases of plant-related toxicoses suffered by ruminant animals where there...