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Filtering by: Subject Ribonucleoside diphosphate reductase -- Regulation

Regulation of mouse ribonucleotide reductase by allosteric effector-substrate interplay and hypoxia

Creator:

Chimploy, Korakod

Abstract:

In order to maintain genetic stability in eukaryotes, tight regulation of the relative sizes of deoxyribonucleoside triphosphate (dNTP) levels inside the cell is essential for optimal fidelity of DNA replication. Ribonucleotide reductase (RNR) is the enzyme responsible for proportional production of DNA precursors. Studies on regulation of this enzyme, the...

Resource Type:

Dissertation

Full Text:

Regulation of Mammalian Ribonucleoside Diphosphate Reductase by Nucleoside Triphosphates Analyzed by The Four
DNA UV damage-related control of ribonucleotide reductase : possible relationship to mutagenesis and the incidence of and attitudes toward skin cancer in several western nations

Creator:

Stenberg, John C.

Abstract:

Two strains of Escherichia coli were studied to determine the effect of constitutive expression of the SOS DNA damage repair response on the activity of ribonucleotide reductase. Activity of the reductase and cellular deoxynucleoside triphosphate (dNTP) pools were both determined before and after exposure of the cells to ultraviolet radiation....

Resource Type:

Honors College Thesis

Full Text:

corresponding ribonucleoside diphosphate (rNDP). Ribonucleotides are at least five times more abundant in