Experimental infection of mice with Candida albicans leads
to significant suppression of cell mediated immune responses.
We have characterized the nature of this candida-induced
suppression with formalin killed Candida albicans (FKCA) in the
yeast and mycelia' phase. Mice (BALB/c or C57B1/6J) treated
with FKCA exhibited a reduction in the T-cell...
Many methods in use today for the isolation, purification, and
identification of the staphylococcal enterotoxins involve lengthy
steps with significant loss of enterotoxin, are subject to interference
from contaminating sample components, and lack sufficient specificity.
Culture extracts of enterotoxin producing Staphylococcus
aureus strains (enterotoxins A-E), crude enterotoxin preparations
(enterotoxins A-E),...
The past decade of research has potentiated a revolution in our understanding of mammalian health and evolution by revealing that the gut microbiome plays a central role in mammalian physiology. Our ability to unlock this potential hinges upon the identification of specific groups of gut microbes that elicit effects on...
Agricultural and companion animals are integral to our way of life as they provide us with nourishment, financial resources, transportation, and companionship. However, pets, managed animals in the agricultural industry, as well as wild populations of food animals are all subject to health and mortality risks. The gut microbiome is...
Benzo[a]pyrene (B[a]P) is a common environmental pollutant produced from the incomplete combustion of organic matter, such as fossil fuel emissions. In vertebrates, B[a]P exposure is associated with hyperactivity, though the underlying mechanisms driving this effect are undescribed. Mounting evidence indicates that the gut microbiome, which is the diverse community of...
Microscopic organisms inhabit virtually every niche on this planet, where they perform functions vital to all life on earth. Accordingly, humans host a complex community of microorganisms (i.e. the gut microbiome) that inhabit the gastrointestinal tract and modulate host physiology. Insight into the specific mechanisms through which gut microbes influence...
Investigations of 16S rRNA gene sequences hallmark modern microbiology. These sequences provide culture-independent insight into the abundance and distribution of microbiota and serve as a principle resource through which microbial community diversity is measured. Consequently, researchers rely on 16S gene sequences to test hypotheses rooted in ecology, evolution, and disease....