Blastocystis spp. is a common intestinal parasite in humans and animals that has been associated with acute or chronic digestive disorders such as irritable bowel syndrome. Serotonin mediates intestinal motility, sensation, and secretory function in the normal intestinal tract. Serotonin (5-HT) signaling is decreased in animal models of colitis, as...
The neuroendocrine system of the gut plays a significant role in regulating intestinal motor and sensory functions, as well as modulating inflammation in the intestine. The intestinal mucosa is the dominant site of serotonin (5HT) synthesis in mammals, with more than 95% of the intestinal 5HT being present in the...