Two trials were conducted over consecutive years to examine the effects of ewe
body condition and post-mating nutrition on ovulation rates and embryo survival. Trial 1
used 146 Polypay ewes ranging in age from 5 to 8 years in a 3 x 2 factorial array of pre-mating
(high-H, low flushed-LF...
Expression of membrane-type matrix metalloproteinases (MT) and tissue inhibitors of matrix metalloproteinases (TIMP) was evaluated in sheep embryos and uterus during the pre- and peri-implantation periods. Embryos and uterine samples were surgically collected from ewes on days 9, 11, 13, and 15 of pregnancy (n=3 ewes/day) and of the estrous...
Experiments were conducted to determine whether endogenous progesterone regulates synthesis and/or secretion of luteal oxytocin (OT). In experiment 1, mature ewes (n=5 per group) were assigned randomly to control or mifepristone (RU 486) treatment groups. Ewes were injected twice daily s.c. with vehicle or 10 mg RU 486 from days...
Effects of progesterone (P₄) and mifepristone (RU 486) on binding
of oxytocin (OT) to its ovine uterine receptor (OTR) were studied in two
experiments. Two additional experiments were conducted to evaluate
specific binding sites for P4 in endometrial plasma membranes. In Exp.
1, ovariectomized ewes were injected with estradiol-17β (E₂)...
Embryonic loss of potential lambs resulting in partial failure of multiple ovulations is a significant factor in the reproductive rate of prolific breeds. The roles of genetic and nutritional variation (and their possible interaction) on embryonic loss were studied by mating blackface and whiteface ewes of either high or low...