Index Catalog // ScholarsArchive@OSU

Impact of Unfolded Protein Response, USP14, and NEDD8 Inhibitors Upon Antigen Presentation in SaI/Ak and 4T1 Tumor Cell Lines

Creator:: Godil, Jamila A.
Abstract:: Antigen presentation is a mechanism used by cells to present peptides on the cell surface. Peptides, derived from both viral or self-proteins are presented on the cell surface by MHC Class I molecules to be recognized and detected by cytotoxic T cells. T cells comprise the defense system to protect...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Natalia Shulzhenko, Committee Member, representing Biomedical Sciences

The legacy of Dr. Francis Hole : examining soil organic carbon after 50 years of detrital manipulation

Creator:: Townsend, Kimberly L.
Abstract:: Models of ecosystem carbon (C) balance generally assume a strong relationship between net primary productivity (NPP), litter inputs, and soil C accumulation, but there is little direct evidence for such a coupled relationship. Using a unique 50-year detrital manipulation experiment in a in a mixed deciduous forest and restored prairie...
Resource Type:: Masters Thesis

Effect of Audible Static on Blood Pressure Measurement by Doppler Ultrasound Sphygmomanometry in Cats

Creator:: Uematsu, Sayaka
Abstract:: Systemic hypertension, a persistent elevation in systemic arterial blood pressure (BP), is a well-recognized disorder in cats. Failing to diagnose it accurately could lead to organ damage or unnecessary lifelong therapy. Doppler ultrasonic flow detectors are commonly used for indirect BP measurements in cats. However, whether the audible static from...
Resource Type:: Masters Thesis

Development and implementation of a transkingdom network analysis pipeline to identify drivers of disease

Creator:: Newman, Nolan K.
Abstract:: The gut microbiome has been previously implemented in a number of diseases. Of note is its substantial role in metabolic syndrome, which encapsulates a group of conditions that increase the risk of cardiovascular disease, type 2 diabetes, and stroke. Understanding the causal relationships between the gut microbiome and host processes...
Resource Type:: Dissertation
Full Text:: to Dr. Andrey Morgun, Dr. Natalia Shulzhenko, Dr. Kevin Brown, Dr. Maude David, and Dr. Cecily

Western Diet-Induced Nonalcoholic Steatohepatitis (NASH): The Impact of Time on the Onset and Remission of Disease

Creator:: Spooner, Melinda H.
Abstract:: Nonalcoholic fatty liver disease (NAFLD) is characterized by an accumulation of neutral lipids in the form of triglycerides and cholesterol esters accounting for >5% of liver weight. Excess neutral lipids accumulate in large lipid droplets, i.e., macrosteatosis, displacing the nucleus of cells. Current theory suggests neutral lipid accumulation is the...
Resource Type:: Dissertation
Full Text:: endeavors of lifelong learning. Next, my committee members Dr. Emily Ho, Dr. Natalia Shulzhenko, Dr

Crossing Boundaries during Stress Responses: Antigen Presentation by Adaptive and Innate MHC Class I Molecules

Creator:: Nagamine, Brandy S.
Abstract:: The immune system is a complex network of cellular processes working in harmony to guard us against pathogenic attack. Of utmost importance is the ability of the immune system to discriminate between “self” and “non-self” and diseased versus healthy. Recognition of antigens complexed to major histocompatibility complex (MHC) molecules is...
Resource Type:: Dissertation
Full Text:: . I am thankful to my committee members, Dr. Natalia Shulzhenko and Dr. Theresa Filtz, for their

Towards a Better Understanding of How the Dietary Supplement Xanthohumol Can Improve Health

Creator:: Logan, Isabelle E.
Abstract:: Xanthohumol, a prenylated flavonoid found in hops and beer, possesses a long-standing reputation to improve health. Xanthohumol’s cytotoxicity to a wide variety of cancer cell lines is well-established. Herein we provide further insight into the cytotoxicity of not only xanthohumol, but also its non-estrogenic derivatives, to a number of colonic...
Resource Type:: Dissertation
Full Text:: , Adrian F. Gombart, Natalia Shulzhenko, and Jan F. Stevens designed the experiments. Isabelle Logan

Identification of Cervical Cancer Key Regulators using Network Biology Approach

Creator:: Vyshenska, Dariia
Abstract:: Cervical cancer is the fourth most common cancer in women worldwide with human papillomavirus (HPV) being the main cause of the disease. Currently available treatment methods are limited and emphasize the need for discovery of new therapies that improve patient outcome. Chromosomal amplifications have been identified as a source of...
Resource Type:: Dissertation
Full Text:: paper, approved the final draft. Natalia Shulzhenko supervised literature revision, authored or

Development of thermosensitive injectable hydrogel and transdermal controlled release formulations for Tacrolimus

Creator:: Nguyen, Duc X.
Abstract:: TAC is the most commonly used medication in post transplantation maintenance immunosuppression therapy. TAC lipophilicity and its erratic oral absorption especially in the presence of food intake result in great intra- and interpatient pharmacokinetic variations. Complicated dosing and frequent required therapeutic monitoring is thought to be the main cause of...
Resource Type:: Dissertation
Full Text:: , Dr. David Lee, and Dr. Natalia Shulzhenko for providing me with valuable insights and for guiding

ScholarsArchive@OSU

Impact of Unfolded Protein Response, USP14, and NEDD8 Inhibitors Upon Antigen Presentation in SaI/Ak and 4T1 Tumor Cell Lines

The legacy of Dr. Francis Hole : examining soil organic carbon after 50 years of detrital manipulation

Effect of Audible Static on Blood Pressure Measurement by Doppler Ultrasound Sphygmomanometry in Cats

Development and implementation of a transkingdom network analysis pipeline to identify drivers of disease

Western Diet-Induced Nonalcoholic Steatohepatitis (NASH): The Impact of Time on the Onset and Remission of Disease

Crossing Boundaries during Stress Responses: Antigen Presentation by Adaptive and Innate MHC Class I Molecules

Towards a Better Understanding of How the Dietary Supplement Xanthohumol Can Improve Health

Identification of Cervical Cancer Key Regulators using Network Biology Approach

Development of thermosensitive injectable hydrogel and transdermal controlled release formulations for Tacrolimus

Limit your search

Academic Affiliation

Advisor

Commencement Year

Committee Member

Conference Name

Conference Section/Track

Creator

Contributor

Date

Decade

Degree Field

Degree Level

Degree Name

Language

License

Location

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Subject

Search Constraints

Search Results

Limit your search