Index Catalog // ScholarsArchive@OSU

Creator:: Roberts, Blaine R.
Abstract:: Oxygen derived radicals are involved in many aspects of life from aging and cell signaling to disease states as diverse as heart disease, diabetes, neurodegeneration and inflammation. Therefore, understanding the function of antioxidant defense proteins and the effects of oxygen derived radicals on protein function is essential to elucidate the...
Resource Type:: Dissertation
Full Text:: Enzymes; Copper, Zinc Superoxide Dismutase and Alkyl Hydroperoxide Reductase Flavoprotein. Abstract

Creator:: Robinson, Kristine M.
Abstract:: Mutations to superoxide dismutase were the first proven cause of Lou Gehrig’s disease (amyotrophic lateral sclerosis; ALS) implicating superoxide in the selective death of motor neurons that characterizes ALS. Nitric oxide competes effectively with superoxide dismutase for superoxide to form the powerful oxidant peroxynitrite. Endogenous formation of peroxynitrite can kill...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________________ Joseph S. Beckman Mutations to superoxide dismutase were the first proven cause of Lou

Creator:: Rhoads, Timothy W.
Abstract:: Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by the progressive degeneration of motor neurons. Dominantly-inherited mutations to the antioxidant enzyme Cu,Zn superoxide dismutase (SOD1) cause 3-6% of all ALS cases. The complete mechanism behind the toxicity of mutant SOD1 remains unclear, although significant evidence points to aberrant or...
Resource Type:: Dissertation
Full Text:: enzyme Cu,Zn superoxide dismutase (SOD1) cause 3-6% of all ALS cases. The complete mechanism behind the

Creator:: Wang, Yueju
Abstract:: The effect of increased manganese superoxide dismutase (Mn-SOD) and cytosolic ascorbate peroxidase (cAPX) on various abiotic stresses was studied using transgenic tomato (Lycopersicon esculentum) plants. Transformants were selected in vitro based on kanamycin resistance, confirmed by PCR and northern blot analyses. Northern blots showed an enhanced gene expression of Mn-SOD...
Resource Type:: Dissertation
Full Text:: Leslie H. Fuchigami £/ The effect of increased manganese superoxide dismutase (Mn-SOD) and cytosolic

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