Index Catalog // ScholarsArchive@OSU

Chemical labeling methods and mass spectrometry of mitochondrial thiol proteomes

Creator:: Wang, Jing
Abstract:: Dysfunction of mitochondria has been linked to aging and the pathogenesis of many degenerative diseases. Aside from their primary function in energy production, mitochondria are considered as a major source and target of reactive oxygen and nitrogen species (ROS/RNS) in cells as well. The mitochondrial thiol proteome is a subset...
Resource Type:: Dissertation
Full Text:: on the ion fragmentation behaviors in tandem mass spectrometry (MS/MS). The MS/MS fragmentation

Gas-phase fragmentation chemistry of protonated peptide ions

Creator:: Bythell, Benjamin James
Abstract:: The fragmentation characteristics of protonated peptides have been investigated using tandem mass spectrometry (MS/MS) under various fragmentation regimes and detailed density functional theory (DFT) reaction pathway calculations. The DFT calculations predict novel salt-bridge stabilized transition structures as well as consecutive reactions occurring in proton-bound dimers for some of the ions...
Resource Type:: Dissertation
Full Text:: Protonated Peptides: Collision-Activated- Dissociation & Tandem Mass Spectrometry

Tandem mass spectrometric analysis of protein and peptide adducts of lipid peroxidation-derived aldehydes

Creator:: Wu, Jianyong
Abstract:: The adduction of proteins and other biomolecules by electrophilic lipid peroxidation products such as 4-hydroxy-2-nonenal (HNE), 4-oxo-2-nonenal (ONE), malondialdehyde (MDA) or acrolein (ACR) is thought to be an initiating and/or propagating factor in the pathophysiology of several diseases such as atherosclerosis, diabetes, Alzheimer's, Parkinson's and other age-related disorders. The identification...
Resource Type:: Dissertation
Full Text:: quadrupole a popular choice for precursor ion selection in tandem mass spectrometry. The RF-only mode is

Large volume (1,800 µL) injection HPLC/MS/MS for the quantitative determination of illicit drugs and human urinary biomarkers in municipal wastewater

Creator:: Chiaia Hernandez, Aurea C.
Abstract:: A sensitive, selective, rapid analytical method based on large-volume injection (LVI) liquid chromatography/ tandem mass spectrometry was developed using commercially-available hardware that eliminates the need for either off-line or on-line solid phase extraction. Centrifugation followed by the direct injection of 1,800 µL was used for the quantification of illicit drugs,...
Resource Type:: Masters Thesis
Full Text:: ) liquid chromatography/ tandem mass spectrometry was developed using commercially-available hardware

Analysis of electrophilic compounds using an electron monochromator : mass spectrometer system

Creator:: Mazurkiewicz, Paul H.
Resource Type:: Dissertation
Full Text:: Dr. Max Deinzer and would like to thank the entire mass spectrometry group for their aid and

Characterization of UV-crosslinked protein-nucleic acid interfaces by Maldi MS and ESI MS/MS

Creator:: Gafken, Philip R.
Resource Type:: Dissertation
Full Text:: identify protein regions taking part in crosslinking and electrospray ionization tandem mass spectrometry

A new technique for high performance tandem time-of-flight mass spectrometry

Creator:: Katz, Daniel Louis
Abstract:: The main result of this written dissertation is a mathematical solution to the problem of multiplex recording for high performance tandem time-of-flight mass spectrometry. The prescription is to use a time-lag accelerator in the second stage to match the ion optical properties of the decay fragments to the requirements of...
Resource Type:: Dissertation
Full Text:: Technique for High Performance Tandem Time-of-Flight Mass Spectrometry. Abstract approved. Douglas F

From fossils to phylogenies

Creator:: Goodwin, Baylee N., Besser, August D., and Ramsey, Stephen A.
Abstract:: The research question address in this study is, “To what extent will the use of hands-on activities for introducing concepts in bioinformatics promote student engagement in after-school STEM club settings?” It is hypothesized that high school students' engagement in hands-on bioinformatics activities promotes their awareness of, and interest in, STEM...
Resource Type:: Learning Object and Presentation
Full Text:: ability to discuss and debate the ethics of scientific endeavors. 2. Mass Spectrometry Activity- Using

Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

Creator:: Huang, Lin
Abstract:: Oxidative stress is deﬁned as an imbalance that favors the production of reactive oxygen species (ROS) over an organism's antioxidant defense. ROS have the ability to damage, either directly or indirectly, biomolecules including DNA, proteins, carbohydrates, and lipids. Various pathological conditions and environmental and chronic diseases have been associated with...
Resource Type:: Dissertation
Full Text:: ························································································· 26 Ion mobility-enhanced tandem mass spectrometry for the characterization of peptides modified

Human in vivo Pharmacokinetics of [¹⁴C]Dibenzo[def,p]chrysene by Accelerator Mass Spectrometry Following Oral Micro-Dosing

Creator:: Madeen, Erin, Corley, Richard A., Crowell, Susan, Turteltaub, Kenneth, Ognibene, Ted, Malfatti, Mike, McQuistan, Tammie J., Garrard, Mary, Sudakin, Dan, and Williams, David E.
Abstract:: Dibenzo(def,p)chrysene (DBC), (also known as dibenzo[a,l]pyrene), is a high molecular weight polycyclic aromatic hydrocarbon (PAH) found in the environment, including food, produced by the incomplete combustion of hydrocarbons. DBC, classified by IARC as a 2A probable human carcinogen, has a relative potency factor (RPF) in animal cancer models 30-fold higher...
Resource Type:: Article

ScholarsArchive@OSU

Chemical labeling methods and mass spectrometry of mitochondrial thiol proteomes

Gas-phase fragmentation chemistry of protonated peptide ions

Tandem mass spectrometric analysis of protein and peptide adducts of lipid peroxidation-derived aldehydes

Large volume (1,800 µL) injection HPLC/MS/MS for the quantitative determination of illicit drugs and human urinary biomarkers in municipal wastewater

Analysis of electrophilic compounds using an electron monochromator : mass spectrometer system

Characterization of UV-crosslinked protein-nucleic acid interfaces by Maldi MS and ESI MS/MS

A new technique for high performance tandem time-of-flight mass spectrometry

From fossils to phylogenies

Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

Human in vivo Pharmacokinetics of [¹⁴C]Dibenzo[def,p]chrysene by Accelerator Mass Spectrometry Following Oral Micro-Dosing

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