A set of 30 chemicals whose octanol-water partition
coefficients (log P) are known were injected on a XAD-2
column and a commercially available octadecylsilane
column. Two types of mobile phase were used on the XAD-2
column: buffered and unbuffered acetonitrile in water and
buffered and unbuffered octanol-saturated water passing
over...
Molecular connectivity is a topological descriptor of
a molecule. It has been used as an independent variable
to describe biological activities, physicochemical
parameters (melting points, boiling points, partition
coefficients) and chromatographic retention indices. There
are inherent problems in using molecular connectivity. A
zero connectivity term has two opposing meanings: 1)...