In this dissertation I study evolutionary patterns at genes encoding antimicrobial peptides (AMPs) in frogs. AMPs are short, amphipathic, cationic, secreted proteins that kill bacteria and other pathogens through a non-catalytic mechanism that involves
binding to and disrupting the microbial cell membrane. In many animal taxa, positive selection is much...
Mammalian female reproduction requires preovulatory surges of gonadotropin-releasing hormone (GnRH) from neurons in the preoptic area (POA) of the hypothalamus, initiated by elevated estradiol (E₂). Rising E₂ activates a subset ofsexually dimorphic Kisspeptin neurons in the female, located in the anteroventralperiventricular nuclei (AVPV). Conversely, E₂ negative feedback is mediated by...
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neurons
from a mouse model
Culture neurons
?
Generate an in vitro model of
AVPV and Arc neurons
The AhR is a ligand-activated transcription factor that mediates the potent immunosuppressive effects of TCDD. AhR-dependent changes in gene expression appear to alter the differentiation of CD4+ T cells to induce a population of CD4+CD25+ T regulatory cells (Tregs) that suppress the immune response. Ascertaining if and how the AhR...
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Receptor (AhR)
Method Development in In Vitro Immune Response
Jacob Huber
Dept. of Environmental and
Gynodioecy is a sexual system wherein females coexist with hermaphrodites. It is of interest
not only because male-sterile plants are advantageous in plant breeding but also because it can be a crucial
step in the evolutionary transition to entirely separate sexes (dioecy) from a hermaphroditic ancestor. The
gynodioecious diploid wild...
Whole-genome duplications are radical evolutionary events that have driven speciation and adaptation in many taxa. Higher-order
polyploids have complex histories often including interspecific hybridization and dynamic genomic changes. This chromosomal
reshuffling is poorly understood for most polyploid species, despite their evolutionary and agricultural importance, due to the
challenge of distinguishing...
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Strawberry
Subgenomes Revealed by Dense Targeted Capture Linkage Maps
Tennessen, J. A., Govindarajulu, R
Motivation: The goal of any parentage analysis is to identify as many parent-offspring relationships as possible, while minimizing incorrect assignments. Existing methods can achieve these ends, but require additional information in the form of demographic data, thousands of markers, and/or estimates of genotyping error rates. For many non-model systems, it...
Whole-genome duplications are radical evolutionary events that have driven speciation and adaptation in many taxa. Higher-order
polyploids have complex histories often including interspecific hybridization and dynamic genomic changes. This chromosomal
reshuffling is poorly understood for most polyploid species, despite their evolutionary and agricultural importance, due to the
challenge of distinguishing...
Whole-genome duplications are radical evolutionary events that have driven speciation and adaptation in many taxa. Higher-order
polyploids have complex histories often including interspecific hybridization and dynamic genomic changes. This chromosomal
reshuffling is poorly understood for most polyploid species, despite their evolutionary and agricultural importance, due to the
challenge of distinguishing...
These essays are an attempt to rebuild memories that explore the nature of work and family. They explore how work knocks against the joints of the body and against the joints between family members, and, as time passes, how the next generation inherits the family line of work only to...
This paper deals with finite abstract Witt rings in the case where
-1 = 1 in the square class group.
The results also apply to Witt rings
of quadratic forms over fields where √-1
is in the field.
The concept
of relative rigidity is studied in finite abstract Witt rings...