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Filtering by: Funding statement This work was supported by a grant from the National Institute on Drug Abuse [1P50 DA018165], and NIH/VA Interagency Agreement [ADA 12013], a V.A.Merit Review [1I01BX000939-01] and the V.A. Research Career Scientist Program (AJ), and by the Bill and Melinda Gates Foundation (TMZ).

Mefloquine and psychotomimetics share neurotransmitter receptor and transporter interactions in vitro

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Janowsky, Aaron, Eshleman, Amy J., Johnson, Robert A., Yang, Jongtae, Zabriskie, T. Mark, Johnson, Robert A., Wolfrum, Katherine M., Hinrichs, David J., Smilkstein, Martin J., and Riscoe, Michael K.

Abstract:

Rationale Mefloquine is used for the prevention and treatment of chloroquine-resistant malaria, but its use is associated with nightmares, hallucinations, and exacerbation of symptoms of post-traumatic stress disorder. We hypothesized that potential mechanisms of action for the adverse psychotropic effects of mefloquine resemble those of other known psychotomimetics. Objectives Using...

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[1I01BX000939- 01] and the V.A. Research Career Scientist Program (AJ), and by the Bill and Melinda Gates

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Mefloquine and psychotomimetics share neurotransmitter receptor and transporter interactions in vitro

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