Auparavant le secteur des pêches ne s’intéressait guère qu’aux ressources et aux captures. Nos spécialités étaient des biologistes, des techniciens des pêches ; nos administrations de tutelle étaient celles des marins pêcheurs, nos recherches étaient essentiellement orientées vers la biologie des espèces, l’environnement de leur habitat, les modèles de gestion...
The domestic dog is one of the most popular pets in the world, and many pet owners consider their pets to be members of their family. Studies have suggested that dogs behave like pseudo-children in many contexts. Despite this, there is very little research on how dog owners may behave...
Biologists have long been fascinated with reproductive traits, in part because they are frequently exaggerated or showy, and they commonly vary among closely related species. Exaggerated sexual traits, in particular, have been the focus of intense empirical and theoretical research, but most of this work has focused on traits involved...
This thesis details my investigation of some pharmaceuticals and natural products on the transport of drugs which are substrates of P-glycoprotein (P-gp), such as cyclosporin A (CSA) and digoxin by using Caco-2 and MDCKII-MDR1 drug transport models. Three objectives were performed to address this goal. The first objective was to...
In current nanotoxicology research, there is a lack of standardization in reporting of zebrafish exposure media and sonication practices. This lack of standardization in use and reporting methods has made reproducing nanoparticle (NP) toxicity results between labs a common issue. It is important to have a standardized way of reporting...
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disorder characterized by neuromuscular junction decay, motor neuron death, progressive paralysis, and eventually death of the individual, usually by respiratory failure. Oxidative stress is a prominent hallmark of the disease and is often accompanied and exacerbated by mitochondrial dysfunction and neuroinflammation. This...
Recent advancements in joining operations and additive manufacturing now allow complex metal parts to be built up from raw materials, as opposed to being machined down from solid blocks. This not only opens up the design space, but also allows for much more efficient manufacturing. By decomposing a complex part...
A semi-parametric PAR diffuse radiation model
was developed using commonly measured climatic variables
from 108 site-years of data from 17 AmeriFlux sites. The
model has a logistic form and improves upon previous efforts
using a larger data set and physically viable climate
variables as predictors, including relative humidity, clearness
index,...
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The promise of epigenome-wide association studies (EWAS) and cancer specific somatic changes in improving our understanding of cancer coupled with the decreasing cost and increasing coverage of DNA methylation microarrays, has brought about a surge in the use of these technologies. Here, we aim to provide both a review of...
Hallmarks of aging include the accumulation of aberrant proteins and a lower resistance to stresses. Because the endoplasmic reticulum (ER) functions to fold proteins and possesses unique stress sensing pathways, the central hypothesis of this dissertation is that the ER is a target of cellular aging and significantly underlies these...