The entire human population is chronically exposed to various
contaminants, including lead and chlorinated hydrocarbon pesticides.
Studies were undertaken to assess the effects of chronic exposure to
lead on the toxicities of two such pesticides, lindane and dieldrin.
Mice were given lead as the acetate in drinking water, at levels...
The toxicity of chlorobenzene (CB) was investigated in rainbow
trout following acute ip administration (1. 0 ml/kg, 1:1 in corn oil)
and chronic exposure (2. 1 ppm and 2. 9 ppm) via the water in a continuously
flowing system for 15 and 30 days.
In the acute study, overt toxicity...
Five varieties of industrial hemp (Cannabis sativa) were grown in the field in Imperial Valley, CA, USA in order to determine whether light conditions or harvest times influence cannabinoid content. A total of 16 cannabinoids were investigated in this study: Delta-9-tetrahydrocannibinol (THC-d9), Delta-9-tetrahydrocannibinolic acid (THC-a), Cannabidiol (CBD), Cannabidiolic acid (CBD-a),...
The utero-ovarian vasculature of domestic animals has been a
popular research subject, especially concerning the roles of the uteroovarian
artery and vein in the unilateral luteolytic phenomenon
demonstrated in these animals. No reports in the literature, however,
have been found regarding the smooth muscle physiology of these vessels.
The present...
Tissue distribution studies of calcium and lead in brain tissue
of rats were increased subsequent to a single intravenous injection
of lead, 10 mg/kg, in the form of lead acetate. Time-course
studies demonstrated that brain concentrations of calcium and lead
(in terms of wet tissue weight) were found to be...
The relationship of intracellular drug levels and resultant drug activity to intracellular pH (pHi) was studied in the experimental tumors. Glucose (5 g/kg) and/or sodium oxamate (0.1 mmol) were administered to Walker 256 ascites cells and Ehrlich ascites cells, in an attempt to alter pHi as measured by the distribution...
There has been no toxicologic proof that the long-term, low-level
exposure of man to chlorophenothane (DDT) is linked with an
increased susceptibility to toxicity or disease. Acute pretreatment
of rats with 75-100 mg/kg DDT has been demonstrated to potentiate
CCI₄-induced hepatotoxicity in that species (McLean and McLean,
1966). Since the...